Product Name	NMDAR3A
Chinese Name	谷氨酸受体3A抗体
Alias	Chi-1; Glutamate [NMDA] receptor subunit 3A; GRIN3A; N-methyl-D-aspartate receptor; N-methyl-D-aspartate receptor subtype 3A; NMD3A_HUMAN; NMDAR-L; NMDAR-L1; NMDAR3A; NR3A.
literatures	Specific References  (2)     |     SL12100R has been referenced in 2 publications. [IF=8.469] Lei, Hanqi. et al. CRISPR screening identifies CDK12 as a conservative vulnerability of prostate cancer. Cell Death Dis. 2021 Jul;12(8):1-11  WB ;  Human.   PubMed:34315855 [IF=2.48] Liao et al. N-Methyl-D-aspartate Receptor Excessive Activation Inhibited Fetal Rat Lung Development In Vivo and In Vitro. (2016) Biomed.Res.Int. 2016:5843981  WB ;  Rat.   PubMed:27478831
Research Area	Neurobiology  Channel protein  The cell membrane受体
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Mouse,  (predicted: Human, Rat, Dog, Rabbit, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	123kDa
Cellular localization	cytoplasmic The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human NMDAR3A/NR3A: 531-630/1115 <Extracellular>
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	NR3A is a subunit of the N-methyl-D-aspartate (NMDA) receptors, which belong to the superfamily of glutamate-regulated ion channels and function in pathological and physiological processes in the central nervous system. NR3A is a multi-pass membrane protein that is expressed in fetal brain and is mediated by glycine. It may be involved in the development of dendritic spines and in the PPP2CB-NMDAR mediated signaling mechanism. NR3A forms a heteromeric channel composed of a Ω subunit (GRIN1), an e subunit (GRIN2A, GRIN2B, GRIN2C or GRIN2D) and a third subunit (GRIN3A or GRIN3B). The NR3A protein is enriched in post-synaptic plasma membrane and post-synaptic densities and requires the presence of GRIN1 to be targeted at the plasma membrane. The NR3A subunit displays greater than 90% sequence homology to the corresponding subunit in rat. Function: NMDA receptor subtype of glutamate-gated ion channels with reduced single-channel conductance, low calcium permeability and low voltage-dependent sensitivity to magnesium. Mediated by glycine. May play a role in the development of dendritic spines. May play a role in PPP2CB-NMDAR mediated signaling mechanism. Subunit: Forms heteromeric channel of a zeta subunit (GRIN1), a epsilon subunit (GRIN2A, GRIN2B, GRIN2C or GRIN2D) and a third subunit (GRIN3A or GRIN3B). Does not form functional homomeric channels. Found in a complex with GRIN1, GRIN2A or GRIN2B and PPP2CB. Probably interacts with PPP2CB. No complex with PPP2CB is detected when NMDARs are stimulated by NMDA Subcellular Location: Cell membrane. Cell junction > synapse > postsynaptic cell membrane. Cell junction > synapse > postsynaptic cell membrane > postsynaptic density. Enriched in post-synaptic plasma membrane and post-synaptic densities. Requires the presence of GRIN1 to be targeted at the plasma membrane. Post-translational modifications: N-glycosylated. Similarity: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. NR3A/GRIN3A subfamily. SWISS: O60391 Gene ID: 116443 Database links: Entrez Gene: 116443 Human Entrez Gene: 116444 Human Omim: 606650 Human Omim: 606651 Human SwissProt: O60391 Human SwissProt: Q8TCU5 Human
Product Picture	Sample: Testis (Mouse) Lysate at 40 ug Primary: Anti- NMDAR3A (SL12100R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 123 kD Observed band size: 123 kD Sample:Placenta (Mouse)Lysate at 40 ug Primary: Anti-NMDAR3A(SL12100R)at 1/300 dilution Secondary: IRDye800CW Goat Anti-RabbitIgG at 1/20000 dilution Predicted band size: 123kD Observed band size: 123kD

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