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Product Name GABRG3 Chinese Name G氨基丁酸受体γ3/GABAA Rγ3抗体 Alias GABA A Receptor gamma 3; GABA(A) receptor; GABA(A) receptor subunit gamma 3; GABR G3; GABRG 3; GABRG3; Gamma aminobutyric acid (GABA) A receptor gamma 3; Gamma aminobutyric acid A receptor gamma 3; Gamma aminobutyric acid receptor subunit gamma 3; GBRG3_HUMAN. Research Area Neurobiology Channel protein The cell membrane受体 G protein-coupled receptor G protein signal Immunogen Species Rabbit Clonality Polyclonal React Species Human, (predicted: Mouse, Rat, ) Applications WB=1:500-2000 ELISA=1:5000-10000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 52kDa Cellular localization The cell membrane Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human GABRG3/GABA A Receptor gamma 3: 31-130/467 <Extracellular> Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail This gene encodes a gamma-aminobutyric acid (GABA) receptor. GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. GABA-A receptors are pentameric, consisting of proteins from several subunit classes: alpha, beta, gamma, delta and rho. The protein encoded by this gene is a gamma subunit, which contains the benzodiazepine binding site. Two transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Aug 2012]
Function:
GABA A Receptor gamma 3, is the ligand-gated ion channel that GABA A (gamma aminobutyric acid) exerts its inhibitory neurotransmitter funtion through.
Subunit:
Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho.
Subcellular Location:
Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Post-translational modifications:
May be palmitoylated
Similarity:
Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRG3 sub-subfamily.
SWISS:
Q99928
Gene ID:
2567
Database links:Entrez Gene: 2567 Human
Entrez Gene: 14407 Mouse
Omim: 600233 Human
SwissProt: Q99928 Human
SwissProt: P27681 Mouse
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