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Product Name GABRA6 Chinese Name G氨基丁酸A型受体α6/GABAA Rα6抗体 Alias GABA A; GABA A Receptor alpha 6 polypeptide; GABA A receptor alpha 6; GABA A receptor subunit alpha 6; GABA subunit A receptor alpha 6; GABA(A) receptor subunit alpha-6; GABRA 6; GABRA6; Gamma aminobutyric acid A receptor alpha 6; Gamma aminobutyric acid GABA A receptor alpha 6; Gamma aminobutyric acid receptor subunit alpha 6; Gamma-aminobutyric acid receptor subunit alpha-6; GBRA6_HUMAN; MGC116903; MGC116904. Research Area Neurobiology The cell membrane受体 Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Mouse, Rat, Dog, Pig, Cow, Rabbit, Sheep, ) Applications WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 49kDa Cellular localization The cell membrane Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human GABRA6/GABA A Receptor alpha 6: 85-180/453 <Extracellular> Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified. [provided by RefSeq, Jul 2008]
Function:
GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.
Subunit:
Binds UBQLN1 (By similarity). Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho.
Subcellular Location:
Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Similarity:
Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRA6 sub-subfamily.
SWISS:
Q16445
Gene ID:
2559
Database links:Entrez Gene: 2559 Human
Entrez Gene: 14399 Mouse
Omim: 137143 Human
SwissProt: Q16445 Human
SwissProt: P16305 Mouse
Unigene: 90791 Human
Unigene: 4915 Mouse
Unigene: 29890 Rat
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