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Product Name 5HT6 Receptor Chinese Name 5-羟色胺受体6抗体 Alias SR-6; 5 HT 6; 5 HT6; 5 hydroxytryptamine 6 receptor; 5 hydroxytryptamine receptor 6; 5-HT-6; 5-HT6; 5-hydroxytryptamine receptor 6; 5HT 6; 5HT6R_HUMAN; HTR 6; HTR6; Serotonin receptor 6. literatures Specific References (1) | SL12058R has been referenced in 1 publications.[IF=3.707] Zhang Yuxiang. et al. The 5-HT6 Receptors in the Ventrolateral Orbital Cortex Attenuate Allodynia in a Rodent Model of Neuropathic Pain. Front Neurosci-Switz. 2020 Aug;14:884 IF ; Rat.Research Area Neurobiology The cell membrane受体 G protein-coupled receptor The new supersedes the old G protein signal Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Mouse, Rat, Dog, Pig, Horse, ) Applications WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 47kDa Cellular localization The cell membrane Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human 5HT6 Receptor/SR-6: 51-150/440 <Extracellular> Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail This gene encodes a protein that belongs to the seven-transmembrane G protein-coupled receptor family of proteins. The encoded protein couples with the Gs alpha subunit and stimulates adenylate cyclase to activate the cyclic AMP-dependent signaling pathway. This receptor is thought to regulate cholinergic neuronal transmission in the brain. Several antidepressants and antipsychotic drugs have a high affinity for this receptor. [provided by RefSeq, Aug 2013]
Function:
This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase. It has a high affinity for tricyclic psychotropic drugs.
Subcellular Location:
Cell membrane; Multi-pass membrane protein.
Tissue Specificity:
Expressed in several human brain regions, most prominently in the caudate nucleus.
Similarity:
Belongs to the G-protein coupled receptor 1 family.
SWISS:
P50406
Gene ID:
3362
Database links:Entrez Gene: 3362 Human
Entrez Gene: 15565 Mouse
Omim: 601109 Human
SwissProt: P50406 Human
SwissProt: Q9R1C8 Mouse
Unigene: 22180 Human
Unigene: 291096 Mouse
Unigene: 10552 Rat
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