Product Name	5HT1E Receptor
Chinese Name	5-羟色胺受体1E抗体
Alias	SR-1E; 5 hydroxytryptamine (serotonin) receptor 1E; 5 hydroxytryptamine (serotonin) receptor 1E G protein coupled; 5 hydroxytryptamine 1E receptor; 5-HT-1E; 5-hydroxytryptamine receptor 1E; HTR1E; S31; Serotonin receptor 1E; 5HT1E_HUMAN.
Research Area	Neurobiology  Signal transduction  G protein-coupled receptor  The new supersedes the old  G protein signal
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Pig, Cow, Guinea Pig, )
Applications	ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	42kDa
Cellular localization	The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human 5HT1E Receptor/SR-1E: 1-120/365 <Extracellular>
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	The members of the G-protein-coupled receptor family are distinguished by their slow transmitting response to ligand binding. These seven transmembrane proteins include the adrenergic, serotonin and dopamine receptors. The effect of the signaling molecule can be excitatory or inhibitory depending on the type of receptor to which it binds. b-adrenergic bound to adrenaline activates adenylyl cyclase, while a2-adrenergic receptor bound to adrenaline inhibits adenylyl cyclase. Like the a2-adrenergic receptor, serotonin receptor functions are also mediated by G proteins that inhibit the activity of adenylyl cyclase. The serotonin receptors have been classified into several categories, designated SR-1–7 (5HT1–7). Subtypes within the SR-1 group include SR-1A, -1B, -1D, -1E and -1F. Function: This is one of the several different receptors for 5-HT, a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity. The 5-HT1E receptor is expressed in human cortex, caudate, putamen, and amygdala, as well as in dorsal root ganglia and in coronary artery. ESTs have been isolated from human brain cancer libraries. Subcellular Location: Cell Membrane, Multi-pass membrane protein. Similarity: Belongs to the G-protein coupled receptor 1 family. SWISS: P28566 Gene ID: 3354 Database links: Entrez Gene: 3354 Human Omim: 182132 Human SwissProt: P28566 Human Unigene: 1611 Human

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