Product Name	TAGLN3
Chinese Name	神经元蛋白22抗体
Alias	Neuronal protein 22; Neuronal protein NP25; NP22; NP25; TAGL3_HUMAN; TAGLN3; Transgelin 3; Transgelin-3.
Research Area	Neurobiology  Stem cells
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Rat,  (predicted: Human, Mouse, Chicken, Dog, Pig, Cow, Sheep, )
Applications	ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	22kDa
Cellular localization	The nucleus
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human TAGLN3/NP22: 8-110/199
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Transgelin is a homolog of transgelin and is also expressed in smooth muscle cells and by peritoneal B-1 cells. Unlike the other two transgelin proteins, transgelin-3 (also designated TAGLN2, NP22 (neuronal protein 22) or NP25) is predominantly expressed in brain. Transgelin-3 contains a putative Actin-binding domain, two EF-hand motifs, two potential phosphorylation sites and a calponin-homology (CH) domain. Transgelin-3 shares homology with transgelin and Calponin, two cytoskeleton-interacting proteins. Belonging to the calponin family, transgelin-3 colocalizes with Actin and Tubulin, suggesting a possible role for transgelin-3 in neuronal plasticity or as a signaling protein. Due to a varied expression pattern, transgelin-3 may play different roles in the developing and adult brain. Expression of transgelin-3 is upregulated in regions of the human alcoholic brain. Tissue Specificity: Widely expressed in the brain. Expression is increased in the superior frontal cortex of alcoholics, but not in the motor cortex or cerebellum. Similarity: Belongs to the calponin family. Contains 1 calponin-like repeat. Contains 1 CH (calponin-homology) domain. SWISS: Q9UI15 Gene ID: 29114 Database links: Entrez Gene: 29114 Human Entrez Gene: 56370 Mouse Entrez Gene: 63837 Rat Entrez Gene: 515562 Cow Omim: 607953 Human SwissProt: Q3ZBY2 Cow SwissProt: Q9UI15 Human SwissProt: Q9R1Q8 Mouse SwissProt: P37805 Rat Unigene: 169330 Human Unigene: 24183 Mouse Unigene: 10998 Rat
Product Picture	Tissue/cell: Rat brain tissue; 4% Paraformaldehyde-fixed and paraffin-embedded; Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min; Incubation: Anti-TAGLN3 Polyclonal Antibody, Unconjugated(SL12041R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining

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