Product Name	GPR18
Chinese Name	G protein-coupled receptor18抗体
Alias	G protein coupled receptor 18; G-protein coupled receptor 18GPCRW; GPR 18; GPR18; N arachidonyl glycine receptor; NAGly receptor; GPR18_HUMAN; GPCR18.
literatures	Specific References  (1)     |     SL12015R has been referenced in 1 publications. [IF=5.858] Matthieu Bardin. et al. The resolvin D2 – GPR18 axis is expressed in human coronary atherosclerosis and transduces atheroprotection in apolipoprotein E deficient mice. BIOCHEM PHARMACOL. 2022 Jul;201:115075  IHC ;  Human.   PubMed:35525326
Research Area	Cell biology  Neurobiology  Signal transduction  The cell membrane受体  G protein-coupled receptor  G protein signal
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human,  (predicted: Mouse, Rat, Pig, Horse, Rabbit, )
Applications	ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=2ug/Test ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	38kDa
Cellular localization	The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human G protein coupled receptor 18: 131-230/331 <Extracellular>
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	G protein-coupled receptors (GPRs), also known as seven transmembrane receptors, heptahelical receptors or 7TM receptors, comprise a superfamily of proteins that play a role in many different stimulus-response pathways. G protein coupled receptors translate extracellular signals into intracellular signals (G protein activation) and they respond to a variety of signaling molecules, such as hormones and neurotransmitters. GPR18 (G protein-coupled receptor 18), also known as GPCRW, is a 331 amino acid multi-pass membrane protein that belongs to the G-protein coupled receptor family. Expressed abundantly in spleen and testis, GPR18 functions as a receptor for N-arachidonyl glycine and is thought to contribute to the regulation of the immune system. GPR18 activity is mediated by G proteins that specifically inhibit adenylyl cyclase. Function: G protein coupled receptors (GPCRs, or GPRs) contain 7 transmembrane domains and transduce extracellular signals through heterotrimeric G proteins. GPCR GPR18 is a member of this family and has been reported to be expressed at high levels in testis and spleen and at lower levels in other tissues associated with endocrine and immunologic/hematologic functions. It is thought to be a receptor for N arachidonyl glycine. It may contribute to regulation of the immune system. Subcellular Location: Cell membrane; Multi-pass membrane protein. Tissue Specificity: Most abundant in testis and spleen. Highly expressed in CD4 and CD8-positive T-cells as well as CD19-positive B-cells. Similarity: Belongs to the G-protein coupled receptor 1 family. SWISS: Q14330 Gene ID: 2841 Database links: Entrez Gene: 2841 Human Entrez Gene: 110168 Mouse Entrez Gene: 679957 Rat Omim: 602042 Human SwissProt: Q14330 Human SwissProt: Q8K1Z6 Mouse SwissProt: A1A5S3 Rat Unigene: 741589 Human Unigene: 37405 Mouse Unigene: 205907 Rat
Product Picture	Paraformaldehyde-fixed, paraffin embedded (Human brain glioma); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (GPR18) Polyclonal Antibody, Unconjugated (SL12015R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.

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