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Rabbit Anti-SLITRK6 antibody
Rabbit Anti-SLITRK6 antibody
4832410J21Rik; MGC119595; MGC119596; MGC119597; OTTHUMP00000066012; SLIK6_HUMAN; SLIT and NTRK like family member 6; SLIT and NTRK like protein 6; SLIT and NTRK-like protein 6; Slit and trk like 6; Slit and trk like gene 6; SLITRK 6; Slitrk6.
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  • NO.:SL11960R
    Clonality:Polyclonal
    Immunogen Species:Rabbit
    React Species:(predicted: Human,Mouse,Rat,Dog,Pig,Cow,Horse,Rabbit,Sheep,)
    Applications:ELISA IHC-P IHC-F ICC IF
    concentration:1mg/ml
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Product Name SLITRK6
Chinese Name 神经突触相关蛋白SLITRK6抗体
Alias 4832410J21Rik; MGC119595; MGC119596; MGC119597; OTTHUMP00000066012; SLIK6_HUMAN; SLIT and NTRK like family member 6; SLIT and NTRK like protein 6; SLIT and NTRK-like protein 6; Slit and trk like 6; Slit and trk like gene 6; SLITRK 6; Slitrk6.  
Research Area Cell biology  Neurobiology  The cell membrane蛋白  
Immunogen Species Rabbit
Clonality Polyclonal
React Species (predicted: Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep, )
Applications ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight 92kDa
Cellular localization The cell membrane 
Form Liquid
Concentration 1mg/ml
immunogen KLH conjugated synthetic peptide derived from human SLITRK6: 201-300/841 <Extracellular>
Lsotype IgG
Purification affinity purified by Protein A
Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
Product Detail The leucine-rich (LRR) repeat is a 20-30 amino acid motif that forms a hydrophobic å/∫ horseshoe fold, allowing it to accommodate several leucine residues within a tightly packed core. All LRR repeats contain a variable segment and a highly conserved segment, the latter of which accounts for 11 or 12 residues of the entire LRR motif. SLITRK6 (SLIT and NTRK-like family, member 6) is an 841 amino acid single-pass type I membrane protein that contains 16 LRR repeats and belongs to the SLITRK family. Expressed at high levels in select brain tissue, as well as in both adult and fetal lung, SLITRK6 functions to suppress neurite outgrowth, playing a role in the regulation of neuronal function. Multiple isoforms of SLITRK6 exist due to alternative splicing events.

Function:
Suppresses neurite outgrowth.

Subcellular Location:
Membrane; Single-pass type I membrane protein

Tissue Specificity:
In adult brain, highly expressed in putamen with no expression in cerebral cortex. Expressed in adult and fetal lung and fetal liver. Also expressed at high levels in some brain tumors including medulloblastomas and primitive neuroectodermal tumors.

Similarity:
Belongs to the SLITRK family.
Contains 11 LRR (leucine-rich) repeats.
Contains 2 LRRCT domains.
Contains 2 LRRNT domains.

SWISS:
Q9H5Y7

Gene ID:
84189

Database links:

Entrez Gene: 84189 Human

Entrez Gene: 239250 Mouse

Entrez Gene: 290467 Rat

Omim: 609681 Human

SwissProt: Q9H5Y7 Human

SwissProt: Q8C110 Mouse



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