Product Name	SLC25A12
Chinese Name	钙结合Mitochondrion载体蛋白抗体
Alias	AGC1; Araceli hiperlarga; ARALAR; ARALAR1; Calcium binding mitochondrial carrier superfamily member; Calcium-binding mitochondrial carrier protein Aralar1; CMC1_HUMAN; Mitochondrial aspartate glutamate carrier 1; SLC25A12; Solute carrier family 25 member 12; solute carrier family 25, member 12.
Research Area	Tumour  Cell biology  Neurobiology  Signal transduction  Cell type markers  The new supersedes the old
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Dog, Cow, Horse, )
Applications	ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	75kDa
Cellular localization	cytoplasmic The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human SLC25A12/ARALAR: 101-200/678
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Calcium signaling in mitochondria is important in order for it to function in response to a variety of extracellular stimuli. Signaling begins with Ca(2+) entry in mitochondria via the Ca(2+) uniporter followed by Ca(2+) activation of three dehydrogenases in the mitochondrial matrix. ARALAR, the neuronal Ca(2+)-binding mitochondrial aspartate-glutamate carrier, has Ca(2+) binding domains facing the extramitochondrial space and functions in the malate-aspartate NADH shuttle (MAS). ARALAR is encoded by the SLC25A12 gene and is expressed in brain and skeletal muscle. ARALAR is required for the synthesis of brain aspartate and N-acetylaspartatemay and plays a role in myelin formation. It is also essential for the transmission of small Ca(2+) signals to mitochondria via an increase in mitochondrial NADH. In addition, ARALAR is implicated in conferring susceptibility to schizophrenia. Function: Calcium-dependent mitochondrial aspartate and glutamate carrier. May have a function in the urea cycle. Subcellular Location: Mitochondrion inner membrane. Tissue Specificity: High levels in heart and skeletal muscle, low in brain and very low in kidney. DISEASE: Defects in SLC25A12 are the cause of aspartate-glutamate carrier 1 deficiency (AGC1D) [MIM:612949]; also called global cerebral hypomyelination. This syndrome consists of a child severe psychomotor retardation, hypotonia and hypomyelination of the central nervous system. Similarity: Belongs to the mitochondrial carrier family. Contains 4 EF-hand domains. Contains 3 Solcar repeats. SWISS: O75746 Gene ID: 8604 Database links: Entrez Gene: 8604 Human Entrez Gene: 78830 Mouse Entrez Gene: 362145 Rat Omim: 603667 Human SwissProt: O75746 Human SwissProt: Q8BH59 Mouse Unigene: 470608 Human Unigene: 30928 Mouse Unigene: 483680 Mouse

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