Product Name	IL-23
Chinese Name	白介素-23抗体
Alias	Interleukin-23 subunit alpha; Il23a; IL 23; IL 23A; IL23P19; Interleukin 23 alpha subunit p19; JKA3 induced upon T cell activation; P19; SGRF; IL-23 subunit alpha; IL-23-A; IL-23p19; IL23; Interleukin 23 p19 subunit; Interleukin-23 subunit p19; JKA3 induced upon T cell activation; MGC79388; IL23A_HUMAN.
literatures	Specific References  (8)     |     SL1193R has been referenced in 8 publications. [IF=5.396] Tin-Yun Ho. et al. Rosmarinic acid ameliorated psoriatic skin inflammation in mice through the novel inhibition on interleukin-17A/interleukin-17A receptor interaction. FOOD FUNCT. 2022 May;:  IHC ;  Mouse.   PubMed:35674182 [IF=5.195] Feng Huang. et al. NMR-based metabolomic analysis for the effects of moxibustion on imiquimod-induced psoriatic mice. J ETHNOPHARMACOL. 2023 Jan;300:115626  IHC ;  Mouse.   PubMed:10.1016/j.jep.2022.115626 [IF=3.47] Zhang Q et al. Transcriptome Analysis of the Gene Expression Profiles Associated with Fungal Keratitis in Mice Based on RNA-Seq. Invest Ophthalmol Vis Sci . 2020 Jun 3;61(6):32.  IHC-P ;  Mouse.   PubMed:32539135 [IF=3.33] Wang, Mingfei, et al. "Damage effect of Interleukin (IL)-23 on oxygen-glucose deprived cells of the neurovascular unit via IL-23 receptor." Neuroscience (2015).  IHC-P ;  Mouse.   PubMed:25600958 [IF=3.298] Qiu et al. Therapeutic Potential of Pien Tze Huang on Experimental Autoimmune Encephalomyelitis Rat. (2018) J.Immunol.Res. 2018:2952471  IHC ;  Rat.   PubMed:29682587 [IF=3.212] Qi Yin. et al. An immuno-blocking agent targeting IL-1β and IL-17A reduces the lesion of DSS-induced ulcerative colitis in mice. 2021 Apr 20  IHC ;  Mouse.   PubMed:33877484 [IF=2.38] Sun, Jiabing, et al. "A Crucial Role of IL-17 in Bone Resorption During Rejection of Fresh Bone Xenotransplantation in Rats." Cell Biochemistry and Biophysics: 1-7.  IHC-P ;  Rat.   PubMed:25331672 [IF=1.37] Yang, Xiao, et al. "Effect of Iodine Excess on Th1, Th2, Th17, and Treg Cell Subpopulations in the Thyroid of NOD. H-2h4 Mice." Biological Trace Element Research (2014): 1-9.  IHC-P ;  Mouse.   PubMed:24740393
Research Area	Tumour  Cell biology  immunology
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human, Mouse,  (predicted: Rat, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	21kDa
Cellular localization	Secretory protein
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human IL-23: 101-196/196
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	IL23 is a heterodimeric cytokine consisting in two subunits : p40, shared with IL12 and a distinct one p19 (the IL23 subunit). Although IL12 activates naive T cells, the initial description of IL23 was the preferential action on memory T cells to increase IFNg production. In conjunction with IL6 and TGF-beta1, IL23 is necessary to maintain the Th1 lineage. IL23 plays an important role in the inflammatory response against infection, and is implicated in the development of cancerous tumors and auto immune diseases. Over expression of p19 correlates with inflammation in multiple organs and epithelial tissues including skin. Function: Associates with IL12B to form the IL-23 interleukin, an heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to an heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis. Subcellular Location: Secreted. Secreted upon association with IL12B. Tissue Specificity: Secreted by activated dendritic and phagocytic cells and keratinocytes. Also expressed by dermal Langerhans cells (at protein level). Similarity: Belongs to the IL-6 superfamily. SWISS: Q9NPF7 Gene ID: 51561 Database links: Entrez Gene: 51561 Human Entrez Gene: 83430 Mouse Omim: 605580 Human SwissProt: Q9NPF7 Human SwissProt: Q9EQ14 Mouse Unigene: 382212 Human Unigene: 98309 Human Unigene: 125482 Mouse IL23(Interleukin-23)作为一种前炎症cell factor，具有影响机体免疫反应和抗感染作用,白介素23能连接Tumour关联的炎症和Tumour免疫监督缺乏关系的cell factor。存在于很多人类Tumour中，能通过促进血管形成来帮助Tumour生长。
Product Picture	Sample: Lane 1: Mouse Ear tissue lysates Lane 2: Human A431 cell lysates Lane 3: Human Jurkat cell lysates Primary: Anti-IL-23 (SL1193R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 21 kDa Observed band size: 21 kDa Tissue/cell: human rhinopolypus tissue; 4% Paraformaldehyde-fixed and paraffin-embedded; Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min; Incubation: Anti-IL-23 Polyclonal Antibody, Unconjugated(SL1193R) 1:300, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining

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