Product Name	Plexin A4
Chinese Name	神经丛蛋白A4抗体
Alias	FAYV2820; KIAA1550; PLEXA4; Plexin-A4; PlexinA4; PLXA4_HUMAN; PLXNA4; PLXNA4A; PLXNA4B; PRO34003; UNQ2820/PRO34003.
Research Area	Developmental biology  Neurobiology
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Chicken, Dog, Cow, Horse, Sheep, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	210kDa
Cellular localization	The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human Plexin A4: 401-500/1894 <Extracellular>
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Forms a receptor complex with neuropilin-1 and can propagate semaphorin-3A elicited inhibitory signals into cells and neurons. Function: Coreceptor for SEMA3A. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance in the developing nervous system. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm Subunit: Interacts with NRP1 and NRP2 Subcellular Location: Cell membrane; Single-pass type I membrane protein Post-translational modifications: Phosphorylated upon DNA damage, probably by ATM or ATR. Similarity: Belongs to the plexin family. Contains 4 IPT/TIG domains. Contains 3 PSI domains. Contains 1 Sema domain. SWISS: Q9HCM2 Gene ID: 91584 Database links: Entrez Gene: 91584 Human Entrez Gene: 243743 Mouse Entrez Gene: 312213 Rat Omim: 604280 Human SwissProt: Q9HCM2 Human SwissProt: Q80UG2 Mouse Unigene: 511454 Human Unigene: 444029 Mouse

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