Product Name	NOTUM
Chinese Name	背板胶质乙酰酯酶抗体
Alias	NOTUM; notum pectinacetylesterase homolog (Drosophila); Notum pectinacetylesterase homolog; NOTUM_HUMAN.
literatures	Specific References  (1)     |     SL11904R has been referenced in 1 publications. [IF=2.63] Yang Xuesong. et al. Intervention Mechanism of Hunag-Lian Jie-Du Decoction on Canonical Wnt/β-Catenin Signaling Pathway in Psoriasis Mouse Model. EVID-BASED COMPL ALT. 2022;2022:3193572  WB ;  Mouse.   PubMed:35463060
Research Area	Tumour  Cell biology  Neurobiology
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Dog, Cow, Horse, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	54kDa
Cellular localization	Secretory protein
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human NOTUM: 351-450/496
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Notum is a 496 amino acid secreted protein that belongs to the pectinacetylesterase family and may deacetylate GlcNAc residues on cell surface glycans. The gene that encodes Notum consists of approximately 9,334 bases and maps to human chromosome 17q25.3. Encoding more than 1,200 genes, chromosome 17 comprises over 2.5% of the human genome. Two key tumor suppressor genes are associated with chromosome 17, namely, p53 and BRCA1. Tumor suppressor p53 is necessary for maintenance of cellular genetic integrity by moderating cell fate through DNA repair versus cell death. Malfunction or loss of p53 expression is associated with malignant cell growth and Li-Fraumeni syndrome. Like p53, BRCA1 is directly involved in DNA repair, though specifically it is recognized as a genetic determinant of early onset breast cancer and predisposition to cancers of ovary, colon, prostate gland and fallopian tubes. Function: May deacetylate GlcNAc residues on cell surface glycans. Subcellular Location: Secreted. Similarity: Belongs to the pectinacetylesterase family. SWISS: Q6P988 Gene ID: 147111 Database links: Entrez Gene: 147111 Human Entrez Gene: 77583 Mouse Entrez Gene: 303743 Rat Omim: 609847 Human SwissProt: Q6P988 Human SwissProt: Q8R116 Mouse

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