Product Name	DLX4
Chinese Name	DLX4抗体
Alias	Beta protein 1; distal-less homeobox 4; DLX4; DLX4_HUMAN; DLX7; DLX8; Homeobox protein DLX-4; Homeobox protein DLX-7; Homeobox protein DLX-8; Homeobox protein DLX4.
Research Area	Chromatin and nuclear signals  transcriptional regulatory factor
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human,  (predicted: Mouse, Rat, Dog, Cow, Rabbit, )
Applications	ELISA=1:5000-10000 IHC-F=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	26kDa
Cellular localization	The nucleus
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human DLX4: 151-240/240
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Many vertebrate homeo box-containing genes have been identified on the basis of their sequence similarity with Drosophila developmental genes. Members of the Dlx gene family contain a homeobox that is related to that of Distal-less (Dll), a gene expressed in the head and limbs of the developing fruit fly. The Distal-less (Dlx) family of genes comprises at least 6 different members, DLX1-DLX6. The DLX proteins are postulated to play a role in forebrain and craniofacial development. Three transcript variants have been described for this gene, however, the full length nature of one variant has not been described. Studies of the two splice variants revealed that one encoded isoform functions as a repressor of the beta-globin gene while the other isoform lacks that function. [provided by RefSeq, Jul 2008]. Function: May play a role in determining the production of hemoglobin S. May act as a repressor. Subcellular Location: Nucleus (Potential). Tissue Specificity: Expressed in leukemia cells and placenta. Also expressed in kidney and fetal liver. Similarity: Belongs to the distal-less homeobox family. Contains 1 homeobox DNA-binding domain. SWISS: Q92988 Gene ID: 1748 Database links: Entrez Gene: 1748 Human Entrez Gene: 13394 Mouse Entrez Gene: 303469 Rat Omim: 601911 Human SwissProt: Q92988 Human SwissProt: P70436 Mouse Unigene: 591167 Human Unigene: 439766 Mouse DLX4基因的表达异常与乳腺癌、结肠癌以及白血病的发生有关.与AML-急性髓系白血病有一定的相关性，DLX4 在急性髓系白血病有高表达，在急性lymphocyte白血病中无表达，可作为AML的一种分子标志，用于两者的鉴别参考。

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