Product Name	Myelin Protein Zero
Chinese Name	外周髓磷脂P0蛋白/P0蛋白抗体
Alias	peripheral myelin prothein Zero; MPZ; MPP; Myelin P0 protein; CHM; CMT1; CMT1B; DSS; MYELIN GLYCOPROTEIN P-ZERO; MYELIN PROTEIN PERIPHERAL; Myelin protein zero; P0; MYP0_HUMAN.
literatures	Specific References  (6)     |     SL0337R has been referenced in 6 publications. [IF=10.76] Schulz, Alexander, et al. "The importance of nerve microenvironment for schwannoma development." Acta Neuropathologica (2016): 1-19.  IHC-P ;  Mouse.   PubMed:27236462 [IF=9.91] Schulz, Alexander, et al. ʺNeuronal merlin influences ERBB2 receptor expression on Schwann cells through neuregulin 1 type III signalling.ʺ Brain (2013): awt327  IHC-P ;  Human.   PubMed:24309211 [IF=6] Röhr, Dominik, et al. "Sodium‐dependent Vitamin C transporter 2 deficiency impairs myelination and remyelination after injury: Roles of collagen and demethylation." Glia (2017).  WB, IF(ICC) ;  Mouse.   PubMed:28456003 [IF=4.73] Erdal Ayhan Işik. et al. Use of Erythropoietin and Fibrin Glue Mixture for Peripheral Nerve Repair. Plast Reconstr Surg. 2022 Feb;149(2):395-403  IHC ;  Rat.   PubMed:34898529 [IF=3.73] Li, Junhui, et al. "Relationship between neural alteration and perineural invasion in pancreatic cancer patients with hyperglycemia." PLoS One 6.2 (2011): e17385.  IHC-P ;  Human.   PubMed:21386984 [IF=2.27] Chitose, Shun‐ichi, et al. "Recurrent laryngeal nerve regeneration using an oriented collagen scaffold containing Schwann cells." The Laryngoscope (2016).  IHC-P ;  Dog.   PubMed:27861947
Research Area	Neurobiology  Signal transduction
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Mouse, Rat, Dog,  (predicted: Human, Pig, Cow, Horse, Rabbit, Guinea Pig, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	24kDa
Cellular localization	The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human P0 protein: 175-248/248 <Cytoplasmic>
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Myelin protein-zero is the major structural protein of peripheral myelin, accounting for more than 50% of the protein present in the sheath of peripheral nerves. Expression of the gene encoding Myelin protein-zero (MPZ) is restricted to Schwann cells; MPZ is not found in the CNS. An integral membrane glycoprotein of ~28kDa, Myelin protein-zero is thought to link adjacent lamellae and thereby stabilize the myelin assembly. The other 3 major components of myelin are myelin basic protein, myelin proteolipid protein and myelin-associated glycoprotein. Subunit: Homodimer and homotetramer. Subcellular Location: Cell membrane; Single-pass type I membrane protein. Tissue Specificity: Found only in peripheral nervous system Schwann cells. Similarity: Belongs to the myelin P0 protein family. Contains 1 Ig-like V-type (immunoglobulin-like) domain. SWISS: P25189 Gene ID: 4359 Database links: Entrez Gene: 4359 Human Entrez Gene: 17528 Mouse Omim: 159440 Human SwissProt: P25189 Human SwissProt: P27573 Mouse  Unigene: 591486 Human Unigene: 93883 Human Unigene: 9986 Mouse  UniProtKB/Swiss-Prot: P25189.1 成熟的周围神经系统髓鞘主要的蛋白为P0蛋白，分子量28KDa，它具有单个跨膜区，是IgG超家族的成员之一。
Product Picture	Sample: Spinal cord (Rat) Lysate at 40 ug Primary: Anti- Myelin Protein Zero (SL0337R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 24 kD Observed band size: 29 kD Sample: Bone (Mouse) Lysate at 40 ug Primary: Anti-Myelin Protein Zero (Bs- 0337R) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 24 kD Observed band size: 26 kD Sample: Lane 1: Spinal cord (Mouse) Lysate at 40 ug Lane 2: Spinal cord (Rat) Lysate at 40 ug Lane 3: Adipose (Mouse) Lysate at 40 ug Lane 4: Adipose (Rat) Lysate at 40 ug Primary: Anti-Myelin Protein Zero (SL0337R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 28 kD Observed band size: 28 kD

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