TEL: +86 571 56623320 EMAIL: [email protected]
Product Name Adenylate Kinase 1 Chinese Name 腺苷酸激酶-1抗体 Alias AK 1; AK1; AK-1; KAD1_HUMAN; Adenylate kinase isoenzyme 1; Adenylate kinase soluble; ATP AMP transphosphorylase; Myokinase; ATP-AMP transphosphorylase 1. Research Area Tumour Cardiovascular Signal transduction The new supersedes the old Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep, Goat, Monkey, ) Applications ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 21kDa Cellular localization cytoplasmic Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human Adenylate Kinase 1: 131-194/194 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail This gene encodes an adenylate kinase enzyme involved in energy metabolism and homeostasis of cellular adenine nucleotide ratios in different intracellular compartments. This gene is highly expressed in skeletal muscle, brain and erythrocytes. Certain mutations in this gene resulting in a functionally inadequate enzyme are associated with a rare genetic disorder causing nonspherocytic hemolytic anemia. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]
Function:
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Small ubiquitous enzyme involved in energy metabolism and nucleotide synthesis that is essential for maintenance and cell growth.
Subunit:
Monomer.
Subcellular Location:
Cytoplasm.
DISEASE:
Defects in AK1 are the cause of hemolytic anemia due to adenylate kinase deficiency (HAAKD) [MIM:612631].
Similarity:
Belongs to the adenylate kinase family.
SWISS:
P00568
Gene ID:
203
Database links:Entrez Gene: 203 Human
Entrez Gene: 11636 Mouse
Omim: 103000 Human
SwissProt: P00568 Human
SwissProt: Q9R0Y5 Mouse
Unigene: 175473 Human
Unigene: 29189 Mouse
Unigene: 79537 Rat
AK1存在于人类红细胞上及某些组织中的具有遗传多态性的同工酶, 腺苷酸激酶催化 ATP,AMP 和 ADP 的转化,它是维持各种腺苷酸平衡的关键酶。因此,腺苷酸激酶就成为调控腺苷酸库大小的靶标分子。
Scan Wechat Qrcode