Product Name	Neurofascin
Chinese Name	神经束蛋白抗体
Alias	KIAA0756; Neurofascin; Neurofascin homolog; NF; Nfasc; Nfasc protein; NFASC_HUMAN; NRCAML; neurofascin 155 kDa isoform; Neurofascin155; Neurofascin-155; NF-155.
Research Area	Neurobiology
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human, Mouse, Rat,  (predicted: Chicken, Dog, Cow, Horse, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	132/150kDa
Cellular localization	The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human Neurofascin-155: 501-650/1347 <Extracellular>
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Neurofascin is a cell adhesion molecule involved in mediating axon recognition but also signaling axonal contact. Immunoglobulin domain cell adhesion molecule (cam) subfamily; members are components of neural cell adhesion molecules (N-CAM L1), Fasciclin II and the insect immune protein Hemolin. The subfamily also includes receptor domains such as as the extracelluar ligand binding domain of Fibroblast Growth Factor Receptor 2. Members are phylogenetically diverse, occuring throughout metazoa, and are not components of the adaptive immune system molecules found in jawed vertebrates. A predominant feature of most Ig domains is a disulfide bridge connecting 2 beta-sheets with a Trp packing against the disulfide bond. Function: Cell adhesion, ankyrin-binding protein which may be involved in neurite extension, axonal guidance, synaptogenesis, myelination and neuron-glial cell interactions. Subunit: Horseshoe-shaped homodimer. Subcellular Location: Cell membrane; Single-pass type I membrane protein. Similarity: Belongs to the immunoglobulin superfamily. L1/neurofascin/NgCAM family. SWISS: O94856 Gene ID: 23114 Database links: Entrez Gene: 23114 Human Entrez Gene: 269116 Mouse Entrez Gene: 116690 Rat Omim: 609145 Human SwissProt: O94856 Human SwissProt: Q810U3 Mouse SwissProt: P97685 Rat Unigene: 13349 Human Unigene: 326702 Mouse Unigene: 3048 Rat Neurobiology相关蛋白（Neurobiology）
Product Picture	Sample: Cerebellum (Mouse) Lysate at 30 ug Primary: Anti- Neurofascin Polyclonal (SL0289R) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 132/150 kD Observed band size: 136 kD Sample: Cerebral cortex (Mouse) Lysate at 40 ug Primary: Anti-Neurofascin (SL0289R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 132/150 kD Observed band size: 150 kD Sample: Lane 1: Cerebrum (Mouse) Lysate at 40 ug Lane 2: Cerebellum (Mouse) Lysate at 40 ug Lane 3: Cerebrum (Rat) Lysate at 40 ug Lane 4: Cerebellum (Rat) Lysate at 40 ug Primary: Anti-Neurofascin (SL0289R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 132 kD Observed band size: 132 kD Tissue/cell: Rat brain tissue; 4% Paraformaldehyde-fixed and paraffin-embedded; Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37∩ for 20 min; Incubation: Anti-Neurofascin Polyclonal Antibody, Unconjugated(SL0289R) 1:500, overnight at 4∑C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining Tissue/cell: rat spinal cord tissue; 4% Paraformaldehyde-fixed and paraffin-embedded; Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37∩ for 20 min; Incubation: Anti-Neurofascin Polyclonal Antibody, Unconjugated(SL0289R) 1:200, overnight at 4∑C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining

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