Product Name	PACAP-38
Chinese Name	腺苷酸环化酶激活肽-38抗体
Alias	HSPC190; Proapoptotic Caspase Adaptor Protein; PACAP; pERp1; Plasma cell-induced ER protein 1; Plasma cell-induced resident endoplasmic reticulum protein; Plasma cell-induced resident ER protein; Proapoptotic caspase adapter protein; pituitary adenylate cyclase activating polypeptide; PRP-48; PACAP-related peptide; Pituitary adenylate cyclase-activating polypeptide 38; Pituitary adenylate cyclase-activating polypeptide 38; PACAP38; PACA_HUMAN.
literatures	Specific References  (3)     |     SL0200R has been referenced in 3 publications. [IF=9.58] Ernest Y. Lee. et al. PACAP is a pathogen-inducible resident antimicrobial neuropeptide affording rapid and contextual molecular host defense of the brain. P Natl Acad Sci Usa. 2021 Jan;118(1):  IHC ;  Mouse.   PubMed:33372152 [IF=8.039] Yifan Zhu. et al. Discovery of Selective P2Y6R Antagonists with High Affinity and In Vivo Efficacy for Inflammatory Disease Therapy. J MED CHEM. 2023;XXXX(XXX):XXX-XXX  WB ;  Mouse.   PubMed:37078976 [IF=0] PENG Y et al. Effect of electroacupuncture on urodynamics, PACAP-38 and PAC1R of spinal cord in rats with neurogenic bladder ✰. World Journal of Acupuncture - Moxibustion,2018 28(1), 50–54.  WB ;  Rat.   PubMed:10.1016/j.wjam.2018.03.014
Research Area	Cell biology  Neurobiology  Kinases and Phosphatases
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human, Mouse, Rat,  (predicted: Pig, Cow, Sheep, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	5kDa
Cellular localization	Secretory protein
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human PACAP-38: 31-38/38 (162-139/176)
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Pituitary adenylate cyslase Activating polypeptide-27/38, PACAP-27/38 is a neuropeptide that has substantial sequence homology to vasoactive intestinal peptide (VIP).Both VIPand PACAP-38are equipotent at the VCAP-2 receptor, while PAC AP -38 is equipotent to PACAP-27 and more potent than VIP at the PAC-1receptor. The function of PACAP is Stimulates adenylate cyclase in pituitary cells. It belongs to the glucagon family. Function: Binding to its receptor activates G proteins and stimulates adenylate cyclase in pituitary cells. Subunit: Interacts with ADCYAP1R1 (via N-terminal extracellular domain). Subcellular Location: Secreted. Similarity: Belongs to the glucagon family. SWISS: P18509 Gene ID: 116 Database links: Entrez Gene: 116 Human Entrez Gene: 11516 Mouse Entrez Gene: 414283 Pig Entrez Gene: 24166 Rat Omim: 102980 Human SwissProt: P18509 Human SwissProt: O70176 Mouse SwissProt: P41535 Pig SwissProt: P13589 Rat Unigene: 531719 Human Unigene: 727476 Human Unigene: 3407 Mouse Unigene: 37400 Rat 腺苷酸环化酶激活肽是一种可激活垂体腺苷酸环化酶的多肽，有PACAP-27和 PACAP-38两种形式，他们共同具有N端27个氨基酸，属于PACAP/glucagon超级家族。在中枢神经系统分布广泛，其中以下丘脑含量最高。
Product Picture	Sample: Lane 1: Mouse Pituitary Lysates Primary: Anti-PACAP-38 (SL0200R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 5kDa Observed band size: 19kDa Tissue/cell: human kidney tissue; 4% Paraformaldehyde-fixed and paraffin-embedded; Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min; Incubation: Anti-PACPA Polyclonal Antibody, Unconjugated(SL0200R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining Tissue/cell: rat brain tissue; 4% Paraformaldehyde-fixed and paraffin-embedded; Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min; Incubation: Anti-PACAP-38 Polyclonal Antibody, Unconjugated(SL0200R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining Tissue/cell: mouse small intestine tissue;4% Paraformaldehyde-fixed and paraffin-embedded; Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min; Incubation: Anti-PACAP-38 Polyclonal Antibody, Unconjugated(SL0200R) 1:200, overnight at 4°C; The secondary antibody was Goat Anti-Rabbit IgG, Cy3 conjugated(SL0295G-Cy3)used at 1:200 dilution for 40 minutes at 37°C. DAPI(5ug/ml,blue,C-0033) was used to stain the cell nuclei

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