Product Name	PACAP receptor
Chinese Name	腺苷酸环化酶激活肽受体1抗体
Alias	ADCYAP1 R1; ADCYAP1R 1; PACAP-R1; adenylate cyclase activating polypeptide 1 (pituitary) receptor type 1; PAC 1; PAC1; PAC1R; PACAP R 1; PACAP1 R; PACAPR; PACAPRI; Pituitary adenylate cyclase activating polypeptide 1 receptor type I Hiphop; Pituitary adenylate cyclase activating polypeptide receptor; Pituitary adenylate cyclase activating polypeptide type I receptor precursor; PACR_HUMAN.
literatures	Specific References  (2)     |     SL0198R has been referenced in 2 publications. [IF=3.188] Zeqi Tang. et al. Seasonal changes in the expression of PACAP, VPAC1, VPAC2, PAC1 and testicular activity in the testis of the muskrat (Ondatra zibethicus). EUR J HISTOCHEM. 2022 Mar 24; 66(2): 3398  IHC ;  Rat.   PubMed:35502591 [IF=0] PENG Y et al. Effect of electroacupuncture on urodynamics, PACAP-38 and PAC1R of spinal cord in rats with neurogenic bladder ✰. World Journal of Acupuncture - Moxibustion,2018 28(1), 50–54.  WB ;  Rat.   PubMed:10.1016/j.wjam.2018.03.014
Research Area	Cell biology  immunology  Neurobiology  The cell membrane受体  G protein-coupled receptor
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Mouse, Rat,  (predicted: Human, )
Applications	WB=1:500-2000 ELISA=1:5000-10000  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	51kDa
Cellular localization	The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from the middle of human PACAP R1: 251-330/468
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Pituitary adenylate cyclase-activating polypeptide (PACAP) is a neuropeptide belonging to the vasoactive intestinal polypeptide/glucagon/ secretin family. It is widely distributed in the body, and a variety of biological actions have been reported. Recent studies have shown that there is a family of PACAP receptors (PACAPRs), and two members of this family have been identified. This is a receptor for PACAP-27 and PACAP-38. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. May regulate the release of adrenocorticotropin, luteinizing hormone, growth hormone, prolactin, epinephrine, and catecholamine. May play a role in spermatogenesis and sperm motility. Causes smooth muscle relaxation and secretion in the gastrointestinal tract (By similarity). Belongs to the G-protein coupled receptor 2 family. Function: This is a receptor for PACAP-27 and PACAP-38. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. May regulate the release of adrenocorticotropin, luteinizing hormone, growth hormone, prolactin, epinephrine, and catecholamine. May play a role in spermatogenesis and sperm motility. Causes smooth muscle relaxation and secretion in the gastrointestinal tract. Subunit: Interacts (via N-terminal extracellular domain) with ADCYAP1. Subcellular Location: Cell membrane; Multi-pass membrane protein. Tissue Specificity: Most abundant in the brain, low expression in the lung, liver, thymus, spleen, pancreas and placenta. Similarity: Belongs to the G-protein coupled receptor 2 family. SWISS: P41586 Gene ID: 117 Database links: Entrez Gene: 117 Human Entrez Gene: 319095 Cow Entrez Gene: 11517 Mouse Entrez Gene: 24167 Rat Omim: 102981 Human SwissProt: Q29627 Cow SwissProt: P41586 Human SwissProt: P70205 Mouse SwissProt: P32215 Rat Unigene: 377783 Human Unigene: 44245 Mouse Unigene: 88408 Rat Growth factors and hormones（ Growth Factor and Hormones） PACAP 受体分为两个亚型，PACAP-1型受体对PACAP是特异性的，与PACAP的亲和力比VIP高100-1000倍，PACAP-II型受体与PACAP和VIP的亲和力相似，对二者无选择性。此抗体即为前者。
Product Picture	Sample: Lane 1: Mouse Cerebrum tissue lysates Lane 2: Rat Cerebrum tissue lysates Primary: Anti-PACAP receptor (SL0198R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 51 kDa Observed band size: 47 kDa Sample:Cerebrum (Mouse) Lysate at 40 ug Primary: Anti-PACAP receptor(SL0198R)at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 51kD Observed band size: 48kD Tissue/cell: rat brain tissue; 4% Paraformaldehyde-fixed and paraffin-embedded; Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min; Incubation: Anti-PACAP R1/PACAP receptor 1 Polyclonal Antibody, Unconjugated(SL0198R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining

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