Product Name	CD31
Chinese Name	血小板endothelial cells黏附分子1抗体
Alias	platelet endothelial cell adhesion molecule precursor-1; PECAM-1; PECAM1; Adhesion molecule; CD31 antigen; CD31 EndoCAM; Endocam; FLJ34100; FLJ58394; GPIIA; Pecam 1; PECA1_HUMAN; PECAM 1 CD31 EndoCAM; PECA1; Pecam1; Platelet endothelial cell adhesion molecule; Platelet/endothelial cell adhesion molecule 1; Adhesion molecule; Platelet/endothelial cell adhesion molecule.
literatures	Specific References  (75)     |     SL0195R has been referenced in 75 publications. [IF=16.874] Bingcheng Yi. et al. Step-wise CAG@PLys@PDA-Cu2+ modification on micropatterned nanofibers for programmed endothelial healing. BIOACT MATER. 2022 Jul;:  IF ;  Human.   PubMed:10.1016/j.bioactmat.2022.07.010 [IF=16.744] Lubin Zhou. et al. A self-pumping dressing with in situ modification of non-woven fabric for promoting diabetic wound healing. CHEM ENG J. 2022 Dec;:141108  IHC ;  Rat.   PubMed:10.1016/j.cej.2022.141108 [IF=15.304] Xuan Li. et al. ROS-responsive hydrogel coating modified titanium promotes vascularization and osteointegration of bone defects by orchestrating immunomodulation. BIOMATERIALS. 2022 Aug;287:121683  IHC ;  Rat.   PubMed:35870263 [IF=14.919] Lu, Gonggong. et al. An instantly fixable and self-adaptive scaffold for skull regeneration by autologous stem cell recruitment and angiogenesis. NAT COMMUN. 2022 May;13(1):1-20  IF ;  Dog.   PubMed:35523800 [IF=11.322] Zhenyin Chen. et al. Gelatin/sodium alginate composite hydrogel with dynamic matrix stiffening ability for bone regeneration. COMPOS PART B-ENG. 2022 Aug;243:110162  IF ;  Rat.   PubMed:10.1016/j.compositesb.2022.110162 [IF=10.711] Lixuan Chen. et al. An injectable gelatin/sericin hydrogel loaded with human umbilical cord mesenchymal stem cells for the treatment of uterine injury. BIOENG TRANSL MED. 2022 May 18  WB ;  Mouse.   PubMed:10.1002/btm2.10328 [IF=9.587] Zhao, Chenxi. et al. Delayed administration of nafamostat mesylate inhibits thrombin-mediated blood–spinal cord barrier breakdown during acute spinal cord injury in rats. J NEUROINFLAMM. 2022 Dec;19(1):1-20  IF ;  Rat.   PubMed:35842640 [IF=9.417] Ying-Ting Lin. et al. Fabrication of perfusable microvessel networks by mimicking in vivo vasculogenesis using a novel scaffold-wrapping method. MATER DESIGN. 2023 Mar;227:111707  IF ;  Human.   PubMed:10.1016/j.matdes.2023.111707 [IF=9.229] Ling Wang. et al. Ultrashort Peptides and Hyaluronic Acid-Based Injectable Composite Hydrogels for Sustained Drug Release and Chronic Diabetic Wound Healing. Acs Appl Mater Inter. 2021;XXXX(XXX):XXX-XXX  IHC ;  Mouse.   PubMed:34860513 [IF=7.6] Choi, Byung Hyune, et al. "Inhibition of blood vessel formation by a chondrocyte-derived extracellular matrix." Biomaterials (2014).  IHC-P ;  Rabbit.   PubMed:24768193 [IF=7.6] Zhang, Hong, et al. "Dual-delivery of VEGF and PDGF by double-layered electrospun membranes for blood vessel regeneration." Biomaterials (2013).  Rat.   PubMed:23290468 [IF=7.6] Han, Fengxuan, et al. "Performance of a multilayered small-diameter vascular scaffold dual-loaded with VEGF and PDGF." Biomaterials (2013).  Rabbit.   PubMed:23830580 [IF=7.36] Pierre Jean Le Reste. et al. Local intracerebral inhibition of IRE1 by MKC8866 sensitizes glioblastoma to irradiation/chemotherapy in vivo. Cancer Lett. 2020 Dec;494:73  IHC ;  Mouse.   PubMed:32882336 [IF=7.242] Hannah Everwien. et al. Engineering an endothelialized, endocrine Neo-Pancreas: Evaluation of islet functionality in an ex vivo model. Acta Biomater. 2020 Nov;117:213  IHC ;  Rat.   PubMed:32949822 [IF=7.129] Huifeng Yue. et al. Maternal NO2 exposure disturbs the long noncoding RNA expression profile in the lungs of offspring in time-series patterns. ECOTOX ENVIRON SAFE. 2022 Nov;246:114140  IHC ;  Mouse.   PubMed:36209526 [IF=7.097] Hao Cai. et al. Cathepsin B-responsive and gadolinium-labeled branched glycopolymer-PTX conjugate-derived nanotheranostics for cancer treatment. Acta Pharm Sin B. 2021 Feb;11:544  IHC ;  Mouse.   PubMed:33643830 [IF=6.208] Yongxin Guo. et al. Beneficial Effects of Oleosomes Fused with Human Fibroblast Growth Factor 1 on Wound Healing via the Promotion of Angiogenesis. INT J MOL SCI. 2022 Jan;23(21):13152  IHC, IF ;  Rat.   PubMed:36361940 [IF=6.092] Sha Liu. et al. Dual Cross-linked HHA Hydrogel Supplies and Regulates MΦ2 for Synergistic Improvement of Immunocompromise and Impaired Angiogenesis to Enhance Diabetic Chronic Wound Healing. Biomacromolecules. 2020;21(9):3795–3806  IF ;  Mouse.   PubMed:32786521 [IF=6.064] Feng Yanping. et al. Mild-temperature photothermal assisted CuSi nanowires for promoting infected wound healing. FRONT BIOENG BIOTECH. 2023 Mar;11:326  IHC ;  Mouse.   PubMed:36937744 [IF=5.94] Li et al. Repair of lipopolysaccharide-induced acute lung injury in mice by endothelial progenitor cells, alone and in combination with simvastatin. (2013) Ches. 144:876-86  IHC ;  Mouse.   PubMed:23539119 [IF=5.89] Li-Ping Nan. et al. Ti3C2Tx MXene-Coated Electrospun PCL Conduits for Enhancing Neurite Regeneration and Angiogenesis. Front Bioeng Biotech. 2022; 10: 850650  IF ;  Rat.   PubMed:35372318 [IF=5.57] Zhang C et al. Superparamagnetic iron oxide (SPIO) nanoparticles labeled endothelial progenitor cells (EPCs) administration inhibited heterotopic ossification in rats. Nanomedicine. 2019 Aug 7;21:102078.  IHC-P&WB ;  Rat.   PubMed:31400573 [IF=5.195] Haiyue Zhao. et al. Naru-3 inhibits inflammation, synovial hyperplasia, and neovascularization in collagen-induced arthritis in rats. J ETHNOPHARMACOL. 2023 Jul;311:116350  IHC ;  Rat.   PubMed:37019159 [IF=5.168] Wang et al. Targeting neurokinin-3 receptor: a novel anti-angiogenesis strategy for cancer treatment. (2017) Oncotarget. 8:40713-40723  IHC ;  Mouse.   PubMed:28489574 [IF=5.116] Weidong Jiang. et al. MicroRNA-205 mediates endothelial progenitor functions in distraction osteogenesis by targeting the transcription regulator NOTCH2. Stem Cell Res Ther. 2021 Dec;12(1):1-14  IHC ;  Dog.   PubMed:33536058 [IF=5.115] Liang Kong. et al. Tumor Microenvironmental Responsive Liposomes Simultaneously Encapsulating Biological and Chemotherapeutic Drugs for Enhancing Antitumor Efficacy of NSCLC. Int J Nanomed. 2020; 15: 6451–6468  IHC ;  Human.   PubMed:32922011 [IF=5.076] Brumm et al. Astrocytes Can Adopt Endothelial Cell Fates in a p53-Dependent Manner. (2017) Mol.Neurobiol. 54:4584-4596  ICC ;  Mouse.   PubMed:27389775 [IF=5.029] Hanhan Fang. et al. Gut-Spleen Axis: Microbiota via Vascular and Immune Pathways Improve Busulfan-Induced Spleen Disruption | mSphere. MSPHERE. 2022 Dec;:  IF ;  Mouse.   PubMed:36511706 [IF=4.996] Banda Chihena H.. et al. Structural and functional analysis of the newt lymphatic system. SCI REP-UK. 2023 Apr;13(1):1-18  IHC ;  Cynops pyrrhogaster,Xenopus Laevis.   PubMed:37106059 [IF=4.882] Fan Z et al. Novel pre-vascularized tissue-engineered dermis based on stem cell sheet technique used for dermis-defect healingRegen Biomater.2020 Oct 8;7(6):627-638.  IF ;  Rabbit.   PubMed:33365148
Research Area	Tumour  Cardiovascular  Cell biology  immunology  Signal transduction  Stem cells  Cell adhesion molecule  Cell Surface Molecule  glycoprotein  Cell type markers  vascular endothelial cell  t-lymphocyte  endothelial cells
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human, Mouse, Rat, Cow, Rabbit,  (predicted: Dog, Pig, Sheep, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	78kDa
Cellular localization	The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human CD31: 681-738/738 <Cytoplasmic>
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	The protein encoded by this gene is found on the surface of platelets, monocytes, neutrophils, and some types of T-cells, and makes up a large portion of endothelial cell intercellular junctions. The encoded protein is a member of the immunoglobulin superfamily and is likely involved in leukocyte migration, angiogenesis, and integrin activation. [provided by RefSeq, May 2010] Function: Induces susceptibility to atherosclerosis (By similarity). Cell adhesion molecule which is required for leukocyte transendothelial migration (TEM) under most inflammatory conditions. Tyr-690 plays a critical role in TEM and is required for efficient trafficking of PECAM1 to and from the lateral border recycling compartment (LBRC) and is also essential for the LBRC membrane to be targeted around migrating leukocytes. Prevents phagocyte ingestion of closely apposed viable cells by transmitting 'detachment' signals, and changes function on apoptosis, promoting tethering of dying cells to phagocytes (the encounter of a viable cell with a phagocyte via the homophilic interaction of PECAM1 on both cell surfaces leads to the viable cell's active repulsion from the phagocyte. During apoptosis, the inside-out signaling of PECAM1 is somehow disabled so that the apoptotic cell does not actively reject the phagocyte anymore. The lack of this repulsion signal together with the interaction of the eat-me signals and their respective receptors causes the attachment of the apoptotic cell to the phagocyte, thus triggering the process of engulfment). Isoform Delta15 is unable to protect against apoptosis. Modulates BDKRB2 activation. Regulates bradykinin- and hyperosmotic shock-induced ERK1/2 activation in human umbilical cord vein cells (HUVEC). Subunit: Interacts with PTPN11; Tyr-713 is critical for PTPN11 recruitment. Forms a complex with BDKRB2 and GNAQ. Interacts with BDKRB2 and GNAQ. Subcellular Location: Isoform Long: Membrane; Single-pass type I membrane protein. Cell junction. Note=Localizes to the lateral border recycling compartment (LBRC) and recycles from the LBRC to the junction in resting endothelial cells. Isoform Delta15: Cell junction. Note=Localizes to the lateral border recycling compartment (LBRC) and recycles from the LBRC to the junction in resting endothelial cells. Tissue Specificity: Expressed on platelets and leukocytes and is primarily concentrated at the borders between endothelial cells. Isoform Long predominates in all tissues examined. Isoform Delta12 is detected only in trachea. Isoform Delta14-15 is only detected in lung. Isoform Delta14 is detected in all tissues examined with the strongest expression in heart. Isoform Delta15 is expressed in brain, testis, ovary, cell surface of platelets, human umbilical vein endothelial cells (HUVECs), Jurkat T-cell leukemia, human erythroleukemia (HEL) and U937 histiocytic lymphoma cell lines (at protein level). Post-translational modifications: Phosphorylated on Ser and Tyr residues after cellular activation. Phosphorylated on tyrosine residues by FER and FES in response to FCER1 activation (By similarity). In endothelial cells Fyn mediates mechanical-force (stretch or pull) induced tyrosine phosphorylation. Similarity: Contains 6 Ig-like C2-type (immunoglobulin-like) domains. SWISS: P16284 Gene ID: 5175 Database links: Entrez Gene: 5175 Human Entrez Gene: 18613 Mouse Omim: 173445 Human SwissProt: P16284 Human SwissProt: Q08481 Mouse Unigene: 376675 Human Unigene: 514412 Human Unigene: 343951 Mouse 血小板endothelial cells黏附分子-1 ( Platelet/ endothelial cell adhesion molecule, PECAM-1)在血小板、endothelial cells、单核细胞、嗜中性细胞及某些T细胞亚群上表达的质膜glycoprotein，属于免疫球蛋白超基因家族成员，在细胞外结构域中有6个C2亚类免疫球蛋白样保守性同原单位。在炎症应答中起作用。
Product Picture	Sample: U937 (human)Cell Lysate at 40 ug Primary: Anti- CD31 (SL0195R) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 78 kD Observed band size: 135kD Sample: Lane 1: Spleen (Mouse) Lysate at 40 ug Lane 2: Lung (Mouse) Lysate at 40 ug Primary: Anti-CD31 (SL0195R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 78 kD Observed band size: 140 kD Paraformaldehyde-fixed, paraffin embedded (human colon carcinoma); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (CD31) Polyclonal Antibody, Unconjugated (SL0195R ) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining. Paraformaldehyde-fixed, paraffin embedded (human liver); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (CD31) Polyclonal Antibody, Unconjugated (SL0195R ) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining. Paraformaldehyde-fixed, paraffin embedded (human tonsil); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (CD31) Polyclonal Antibody, Unconjugated (SL0195R ) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.

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