Product Name	CRP
Chinese Name	C-反应蛋白抗体
Alias	C-reactive protein; C Reactive Protein; C reactive protein pentraxin related; CRP; MGC88244; PTX 1; PTX1.  C反应蛋白
literatures	Specific References  (8)     |     SL0155R has been referenced in 8 publications. [IF=8.355] Liu X et al. Polydopamine-based molecular imprinted optic microfiber sensor enhanced by template-mediated molecular rearrangement for ultra-sensitive C-reactive protein detection. Chemical Engineering Journal. 2020, May 387: 124074.  antibody-antigen microfibers ;   PubMed:doi:10.1016/j.cej.2020.124074 [IF=5.151] Zhang L et al. The Protective Activities of Dietary Sea Cucumber Cerebrosides against Atherosclerosis through Regulating Inflammation and Cholesterol Metabolism in Male Mice.Mol Nutr Food Res. 2018 Aug;62(16):e1800315.  WB ;  Mouse.   PubMed:29883529 [IF=4.916] Rong Z et al. A C-reactive protein immunosensor based on platinum nanowire/titania nanotube composite sensitized electrochemiluminescence. Talanta, 2019.205, 120135.  Other ;  Human.   PubMed:doi:10.1016/j.talanta.2019.120135 [IF=3.97] Ding, Lin, et al. "Eicosapentaenoic acid-enriched phospholipids improve atherosclerosis by mediating cholesterol metabolism." Journal of Functional Foods 32 (2017): 90-97.  WB ;  Mouse.   PubMed:doi:10.1016/j.jff.2017.02.020 [IF=3.743] Jin Z et al. Geniposide alleviates atherosclerosis by regulating macrophage polarization via the FOS/MAPK signaling pathway. Biomed Pharmacother. 2020 May;125:110015.  ELISA ;  rabbit.   PubMed:32187958 [IF=3.644] Xiaoxuan Lei. et al. Human Salivary Histatin-1 Is More Efficacious in Promoting Acute Skin Wound Healing Than Acellular Dermal Matrix Paste. Front Bioeng Biotech. 2020; 8: 999  IHC ;  Mouse.   PubMed:32974320 [IF=3.241] Zhang L et al. Eicosapentaenoic acid in the form of phospholipid exerts superior anti-atherosclerosis effects than its triglyceride form in ApoE-/-mice. Food & Function. 2019  WB ;  Mouse.   PubMed:31246210 [IF=2.41] Guo, Fang, et al. "Fibrinogen, fibrin, and FDP induce C-reactive protein generation in rat vascular smooth muscle cells: Pro-inflammatory effect on atherosclerosis." Biochemical and biophysical research communications 390.3 (2009): 942-946.  Rat.   PubMed:19852936
Research Area	Cardiovascular  immunology  Signal transduction  Apoptosis  Growth factors and hormones
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human, Mouse,  (predicted: Rat, Dog, Pig, Rabbit, )
Applications	ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	25kDa
Cellular localization	Secretory protein
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human CRP: 125-224/224
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Pentraxins are plasma proteins characterized by their pentameric discoid assembly and their Ca2+ dependent ligand binding, such as Serum amyloid P component (SAP) and C-reactive Protein (CRP), which are cytokine-inducible acute-phase proteins implicated in innate immunity. CRP binds to ligands containing phosphocholine, SAP binds to amyloid fibrils, DNA, chromatin, fibronectin, C4-binding proteins and glycosaminoglycans. "Long" pentraxins have N-terminal extensions to the common pentraxin domain; one group, the neuronal pentraxins, may be involved in synapse formation and remodeling, and they may also be able to form heteromultimers. Function: Displays several functions associated with host defense: it promotes agglutination, bacterial capsular swelling, phagocytosis and complement fixation through its calcium-dependent binding to phosphorylcholine. Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells. Subunit: Homopentamer. Pentaxin (or pentraxin) have a discoid arrangement of 5 non-covalently bound subunits. Subcellular Location: Secreted. Tissue Specificity: Found in plasma. Similarity: Belongs to the pentaxin family. Contains 1 pentaxin domain. SWISS: P02741 Gene ID: 1401 Database links: Entrez Gene: 1401 Human Omim: 123260 Human SwissProt: P02741 Human Unigene: 76452 Human C反应蛋白 CRP（C-reactive protin）是与C性肺炎球菌的多糖起反应的一种蛋白，在某些细菌的感染过程中出现在血浆中。 CRP是在一些病理性情况下出现于病人血清中的一种glycoprotein，特别是在伴有肯炎症和组织坏死疾病的急性期。血清中出现的这种异常蛋白能和肺炎C-多糖体发生沉淀反应，当疾病好转或缓解时，CRP减低或消失。 临床意义: (1)各种急性化脓性炎症、菌血症、组织坏死(心肌梗塞、手术、严重创伤、烧伤等)、恶性Tumour、结缔组织病、肾移殖后急性排异反应、急性风湿热、风湿性关节炎、类风湿性关节炎、心肌炎急性期、肺炎、肺结核、系统性红斑狼疮、急性肝炎和阑尾炎等，血清中CRP含量可增高，它的出现比其它急性期的反应物质早，所以对疾病的早期诊断很有帮助。 CRP可以鉴别细菌炎症或者是病毒性炎症。细菌性炎症CRP可以明显增高，而病毒性炎症CRP的血清含量一般都在正常范围。
Product Picture	Paraformaldehyde-fixed, paraffin embedded (Human liver); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (CRP) Polyclonal Antibody, Unconjugated (SL0155R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining. Tissue/cell: mouse intestine tissue; 4% Paraformaldehyde-fixed and paraffin-embedded; Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min; Incubation: Anti-CRP Polyclonal Antibody, Unconjugated(SL0155R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining Tissue/cell: human lung carcinoma; 4% Paraformaldehyde-fixed and paraffin-embedded; Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min; Incubation: Anti-CRP Polyclonal Antibody, Unconjugated(SL0155R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining

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