Product Name	Calcitonin receptor
Chinese Name	降钙素受体抗体
Alias	Calcitonin receptor precursor; Calcr; CRT; CT R; CTR; CTR1; CALCR_MOUSE; CT-R; CALCR_HUMAN.
literatures	Specific References  (11)     |     SL0124R has been referenced in 11 publications. [IF=14.903] Tong Gao. et al. Macrophage-camouflaged epigenetic nanoinducers enhance chemoimmunotherapy in triple negative breast cancer. ACTA PHARM SIN B. 2022 Nov;:  IF ;  Mouse.   PubMed:10.1016/j.apsb.2022.11.018 [IF=13.116] Yanmei He. et al. A combinational chemo-immune therapy using an enzyme-sensitive nanoplatform for dual-drug delivery to specific sites by cascade targeting. Sci Adv. 2021 Feb;7(6):eaba0776  IF ;  Mouse.   PubMed:33547067 [IF=12.13] Tian Zhang. et al. Supramolecular Tadalafil Nanovaccine for Cancer Immunotherapy by Alleviating Myeloid-Derived Suppressor Cells and Heightening Immunogenicity. 2021 May 13  IHC ;  Mouse.   PubMed:10.1002/smtd.202100115 [IF=8.947] Zhen-Han Feng. et al. A combination strategy based on an Au nanorod/doxorubicin gel via mild photothermal therapy combined with antigen-capturing liposomes and anti-PD-L1 agent promote a positive shift in the cancer-immunity cycle. Acta Biomater. 2021 Oct;:  IF ;  Mouse.   PubMed:34619371 [IF=6.6] Jessika Appelt. et al. Mice Lacking the Calcitonin Receptor Do Not Display Improved Bone Healing. Cells-Basel. 2021 Sep;10(9):2304  IF ;  mouse.   PubMed:34571953 [IF=5.458] Tazio Maleitzke. et al. The calcitonin receptor protects against bone loss and excessive inflammation in collagen antibody-induced arthritis. Iscience. 2022 Jan;25:103689  IHC ;  Mouse.   PubMed:35036874 [IF=3.97] Tsukamoto, Manabu, et al. "Elcatonin prevents bone loss caused by skeletal unloading by inhibiting preosteoclast fusion through the unloading-induced high expression of calcitonin receptors in bone marrow cells." Bone (2016).  IHC-P ;  Mouse.   PubMed:26851124 [IF=2.46] Su, Jiansheng, et al. "Ibuprofen Rescues Abnormalities in Periodontal Tissues in Conditional Presenilin 1 and Presenilin 2 Double Knockout Mice."International Journal of Molecular Sciences?14.9 (2013): 18457-18469.  IHC-P ;  Mouse.   PubMed:24018889 [IF=2.241] Bobek J et al. Onset of calciotropic receptors during the initiation of mandibular/alveolar bone formation. Ann Anat. 2019 Oct 12;227:151427.  IHC-P ;  Mouse.   PubMed:31614180 [IF=0.23] Zhou, Zhen, et al. "The effects of ZJXG decoction on the serum CT levels and the expressions of CTR and Cbfα1 in callus of femur fracture rats." Biomedical Research 27.3 (2016): 762-768.  IHC-P ;  Rat.   PubMed:ISSN0970-938X [IF=0] Wenhuan Chai. et al. Visualizing Cathepsin K-Cre Expression at the Single-Cell Level with GFP Reporters. JBMR Plus. 2022 Dec;:e10706  IF ;  Mouse.   PubMed:36699636
Research Area	Tumour  immunology  Neurobiology  Signal transduction  The cell membrane受体  G protein-coupled receptor
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Rat,  (predicted: Mouse, )
Applications	ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	53kDa
Cellular localization	The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from mouse Calcitonin receptor: 31-120/516 <Extracellular>
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	This gene encodes a high affinity receptor for the peptide hormone calcitonin and belongs to a subfamily of seven transmembrane-spanning G protein-coupled receptors. The encoded protein is involved in maintaining calcium homeostasis and in regulating osteoclast-mediated bone resorption. Polymorphisms in this gene have been associated with variations in bone mineral density and onset of osteoporosis. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2009] Function: This is a receptor for calcitonin. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. The calcitonin receptor is thought to couple to the heterotrimeric guanosine triphosphate-binding protein that is sensitive to cholera toxin. Subunit: Interacts with GPRASP2. Subcellular Location: Cell membrane; Multi-pass membrane protein. Similarity: Belongs to the G-protein coupled receptor 2 family. SWISS: P32214 Gene ID: 12311 Database links: Entrez Gene: 799 Human Entrez Gene: 12311 Mouse Entrez Gene: 116506 Rat Omim: 114131 Human SwissProt: P30988 Human SwissProt: Q60755 Mouse SwissProt: P32214 Rat Unigene: 489127 Human Unigene: 4642 Mouse Unigene: 10062 Rat 降钙素受体（Calcitonin receptor,CT-R)是G protein-coupled receptor，有两种受体亚型，CT-R可与多种配体结合，如CGRP、Amylin、Am等。CT-R在破骨细胞中含量最高，也存在于肾等多种器官组织内。
Product Picture	Paraformaldehyde-fixed, paraffin embedded (Rat testis); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (CALCR) Polyclonal Antibody, Unconjugated (SL0124R) at 1:500 overnight at 4°C, followed by a conjugated secondary (sp-0023) for 20 minutes and DAB staining.

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