Product Name	Calponin 1
Chinese Name	钙调节蛋白-1抗体
Alias	Basic calponin; Calponin-1; Calponin 1 basic smooth muscle; Calponin H1 smooth muscle; Calponin1; Calponins basic; CNN 1; CNN1; Sm Calp; SMCC; CNN1_HUMAN; Calponin H1; Calponin1; Sm Calp; smooth muscle.
literatures	Specific References  (12)     |     SL0095R has been referenced in 12 publications. [IF=10.171] Wan Zhou. et al. Retinol binding protein 4 promotes the phenotypic transformation of vascular smooth muscle cells under high glucose condition via modulating RhoA/ROCK1 pathway. TRANSL RES. 2023 Mar;:  WB ;  Rat.   PubMed:37003483 [IF=8.724] Yinping Zhao. et al. A novel mechanism of inhibiting in-stent restenosis with arsenic trioxide drug-eluting stent: Enhancing contractile phenotype of vascular smooth muscle cells via YAP pathway. Bioact Mater. 2021 Feb;6:375  IF ;  Rabbit.   PubMed:32954055 [IF=8.713] Zhao-Bo Luo. et al. Fecal transplant from myostatin deletion pigs positively impacts the gut-muscle axis. ELIFE. 2023; 12: e81858  WB ;  Mouse.   PubMed:37039469 [IF=4.75] Zhao, Yuechao, et al. "Estrogen-Induced CCN1 is Critical for Establishment of Endometriosis-like Lesions in Mice." Molecular Endocrinology (2014).  IHC-P ;  Mouse.   PubMed:25321413 [IF=4.35] Ning An. et al. Application of iTRAQ Technology to Identify Differentially Expressed Proteins of Sauce Lamb Tripe with Different Secondary Pasteurization Treatments. FOODS. 2022 Jan;11(8):1166  WB ;  Sheep.   PubMed:35454754 [IF=4.315] Huizhu Zhang. et al. Regulatory effects of HIF-1α and HO-1 in hypoxia-induced proliferation of pulmonary arterial smooth muscle cells in yak. Cell Signal. 2021 Nov;87:110140  IF ;  Bovine.   PubMed:34478827 [IF=4.222] Yi Song. et al. LncRNA SENCR overexpression attenuated the proliferation, migration and phenotypic switching of vascular smooth muscle cells in aortic dissection via the miR-206/myocardin axis. Nutr Metab Cardiovas. 2022 Mar;:  WB ;  Other.   PubMed:35351345 [IF=4.07] Syedain, Zeeshan, et al. ʺImplantation of Completely Biological Engineered Grafts Following Decellularization into the Sheep Femoral Artery.ʺ Tissue Engineering (2014).  IHC-F ;  Sheep.   PubMed:24417686 [IF=2.554] Xin-Yue Liu. et al. Positive growth of smooth muscle in uterine horns of myostatin homozygous mutant gilt. RES VET SCI. 2022 Aug;:  IF, WB ;  Pig.   PubMed:36027840 [IF=2.3] Cai, Jinghua, et al. "Regulation of tumorigenesis in oral epithelial cells by defined reprogramming factors Oct4 and Sox2." Oncology Reports  IHC-P ;  Mouse.   PubMed:27279579 [IF=2.22] Hak Myong Choe. et al. Silencing myostatin increases area fraction of smooth muscle in the corpus cavernosum of pigs. ANIM REPROD SCI. 2022 Sep;:107077  IF, WB ;  Pig.   PubMed:36194928 [IF=1.83] HAYASHI, TAKUMA, et al. "Characterization of Leiomyomatoid Angiomatous Neuroendocrine Tumour (LANT)-like Tumour in the Myometrium with Histopathological Examination." Anticancer Research 37.4 (2017): 1765-1772.  IHC ;  Human.   PubMed:28373439
Research Area	Cardiovascular  Signal transduction  Stem cells  Cytoskeleton
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human, Mouse, Rat,  (predicted: Chicken, Dog, Pig, Cow, Sheep, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	33kDa
Cellular localization	cytoplasmic
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human Calponin 1: 201-297/297
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Predicted to enable actin binding activity. Involved in negative regulation of vascular associated smooth muscle cell proliferation. Located in cytoskeleton. [provided by Alliance of Genome Resources, Nov 2021] Function: Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity (By similarity). Subunit: Part of cGMP kinase signaling complex at least composed of ACTA2/alpha-actin, CNN1/calponin H1, PLN/phospholamban, PRKG1 and ITPR1. Tissue Specificity: Smooth muscle, and tissues containing significant amounts of smooth muscle. Similarity: Belongs to the calponin family. Contains 3 calponin-like repeats. Contains 1 CH (calponin-homology) domain. SWISS: P51911 Gene ID: 1264 Database links: Entrez Gene: 1264 Human Entrez Gene: 484937 Dog Entrez Gene: 12797 Mouse Entrez Gene: 396911 Pig Entrez Gene: 65204 Rat Omim: 600806 Human SwissProt: P51911 Human SwissProt: Q08091 Mouse SwissProt: Q08092 Pig SwissProt: Q08290 Rat Unigene: 465929 Human Unigene: 4356 Mouse Unigene: 31788 Rat Calponin1是一种激动蛋白Binding protein，是平滑肌特有的一种蛋白，可以与肌动蛋白、原肌球蛋白和钙调素结合,具有抑制平滑肌细胞收缩的功能，主要用于平滑肌Tumour和乳腺等组织中的肌epithelial cells分布的研究。
Product Picture	Sample: Urinary bladder (Mouse) Lysate at 40 ug Primary: Anti-Calponin 1 (SL0095R) at 1/500 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 33 kD Observed band size: 33 kD Tissue/cell: mouse stomach tissue; 4% Paraformaldehyde-fixed and paraffin-embedded; Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min; Incubation: Anti-Calponin 1 Polyclonal Antibody, Unconjugated(SL0095R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining Tissue/cell: human gastric carcinoma; 4% Paraformaldehyde-fixed and paraffin-embedded; Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min; Incubation: Anti-Calponin 1 Polyclonal Antibody, Unconjugated(SL0095R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining Positive control: H9C2(2% Paraformaldehyde-fixed ) Isotype Control Antibody Antibody: Rabbit IgG; Dilution: 1μg in 100 μl 1 X PBS containing 0.5% BSA Secondary Antibody Antibody: Goat anti-rabbit IgG-FITC; Dilution: 1:200 in 1 X PBS containing 0.5% BSA Primary Antibody Supplier catalog number: SL0095R; Dilution: 1μg in 100 μl 1X PBS containing 0.5% BSA

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