Product Name	Secretin
Chinese Name	分泌素抗体
Alias	SCT; Secretin precursor; SECR_HUMAN; Secr.
literatures	Specific References  (5)     |     SL0088R has been referenced in 5 publications. [IF=14.957] Yuchu  Liu. et al. A gut-brain axis mediates sodium appetite via gastrointestinal peptide regulation on a medulla-hypothalamic circuit. SCI ADV. 2023 Feb;9(7)  IF ;  Mouse.   PubMed:36791202 [IF=14.679] Lixian Chen. et al. Inhibition of secretin/secretin receptor axis ameliorates non‐alcoholic fatty liver disease phenotypes. 2021 Apr 30  IHC ;  Human, Mouse.   PubMed:33928675 [IF=9.071] Lamei Xue. et al. Maternal secretin ameliorates obesity by promoting white adipose tissue browning in offspring. EMBO REP. 2022 Jul;23(7):e54132  IHC ;  Mouse.   PubMed:35652247 [IF=6.4] Zhang et al. The knockout of secretin in cerebellar Purkinje cells impairs mouse motor coordination and motor learning. (2014) Neuropsychopharmacolog. 39:1460-8  IHC-P ;  Mouse.   PubMed:24356714 [IF=0.392] Yildiz, M.. et al. The Effect of Chronic Intermittent Cold Exposure on Gastrin-, Somatostatin-, Secretin-, and Serotonin-Containing Cells in the Small Intestine of Rats. Biol Bull+. 2021 Dec;48(3):S95-S106  IHC ;  Rat.   PubMed:10.1134/S1062359022010174
Research Area	Signal transduction  Growth factors and hormones  Endocrinopathy
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human, Rat,  (predicted: Mouse, Pig, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	13kDa
Cellular localization	Secretory protein
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human Secretin: 28-54/121
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Secretin belongs to the glucagon family. This protein is an endocrine hormone and its major site of production is the endocrine S cells located in the proximal small intestinal mucosa. The release of active secretin is stimulated by either fatty acids or an acidic pH in the duodenum. This hormone stimulates the secretion of bicarbonate-rich pancreatic fluids and has also been shown to regulate the growth and development of the stomach, small intestine, and pancreas. Secretin deficiency has been implicated in autistic syndrome, suggesting that the hormone could have a neuroendocrine function in addition to its role in digestion. Function: Stimulates formation of NaHCO(3)-rich pancreatic juice and secretion of NaHCO(3)-rich bile and inhibits HCl production by the stomach. Subcellular Location: Secreted. Similarity: Belongs to the glucagon family. SWISS: P09683 Gene ID: 6343 Database links: Entrez Gene: 6343 Human Omim: 182099 Human SwissProt: P09683 Human Unigene: 632324 Human Secretin 促胰液素或胰泌素，由十二指肠分泌的一种多肽激素，可刺激胰液的释放。
Product Picture	Sample: Lane 11: Human SW480 cell lysates Lane 12: Human MCF-7 cell lysates Lane 13: Human HepG2 cell lysates Primary: Anti-Secretin (SL0088R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 13 kDa Observed band size: 13 kDa Tissue/cell: rat intestine tissue ; 4% Paraformaldehyde-fixed and paraffin-embedded; Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min; Incubation: Anti-Secrein Polyclonal Antibody, Unconjugated(SL0088R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining

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