Product Name	Nociceptin
Chinese Name	孤菲肽/痛敏肽抗体
Alias	PNOC; N/OFQ; N23K; N23K/N27K; Nociceptin, included; Npnc1; OFQ; OFQ/N; Orphanin FQ; PPNOC; prepronociceptin; Propronociceptin; PNOC_HUMAN.
literatures	Specific References  (1)     |     SL0075R has been referenced in 1 publications. [IF=1.931] Lyu J et al. Botulinum toxin A alleviates orofacial nociception induced by orthodontic tooth movement through nociceptin/orphanin-FQ pathway in rats. Arch Oral Biol . 2020 Sep;117:104817.  WB ;  Rat.   PubMed:32603879
Research Area	Tumour  Cardiovascular  Neurobiology  Signal transduction
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Rat,  (predicted: Human, Mouse, Dog, Pig, Cow, Horse, Rabbit, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	20kDa
Cellular localization	Secretory protein
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human Nociceptin: 130-146/176
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Nociceptin (PNOC) is the ligand of the opioid receptor-like receptor (OPRL1). It may act as a transmitter in the brain by modulating nociceptive and locomotor behavior. May be involved in neuronal differentiation and development. Expressed predominantly in the spinal cord and brain, being more abundant in the hypothalamus and striatum. Also found in small amounts in ovary. Belongs to the opioid neuropeptide precursor family. Function: Nociceptin is the ligand of the opioid receptor-like receptor (OPRL1). It may act as a transmitter in the brain by modulating nociceptive and locomotor behavior. May be involved in neuronal differentiation and development (By similarity). Subcellular Location: Secreted. Tissue Specificity: Predominantly in the brain and spinal cord. Similarity: Belongs to the opioid neuropeptide precursor family. SWISS: Q13519 Gene ID: 5368 Database links: Entrez Gene: 5368 Human Entrez Gene: 18155 Mouse Entrez Gene: 25516 Rat Omim: 601459 Human SwissProt: Q13519 Human SwissProt: Q64387 Mouse SwissProt: Q62923 Rat Unigene: 88218 Human Unigene: 16347 Mouse Unigene: 486163 Mouse Unigene: 87935 Rat 孤菲肽（Nociceptin又称为Orphanin FQ; PPNOC; ORL1）是新发现的一种神经肽，由17个氨基酸组成，又称痛敏肽。消化道Tumour病人的血浆中OFQ含量明显高于对照组，尤以结肠癌、胃癌最为明显。
Product Picture	Sample: Brain(Rat) lysate at 30ug; Liver(Rat) lysate at 30ug; Primary: Anti-Nociceptin(SL0075R) at 1:200 dilution; Secondary: HRP conjugated Goat-Anti-Rabbit IgG(SL0295G-HRP) at 1: 3000 dilution; Predicted band size : 20kD Observed band size : 20kD Tissue/cell: rat brain tissue; 4% Paraformaldehyde-fixed and paraffin-embedded; Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min; Incubation: Anti-Nociceptin Polyclonal Antibody, Unconjugated(SL0075R) 1:300, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining

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