Product Name	MUC6(ready to use)
Chinese Name	粘蛋白6单克隆抗体（工作液）
Alias	Gastric mucin 6 ; Gastric Mucin ; Gastric mucin-6 ; MUC 6 ; MUC-6 ; Muc6 ; MUC6 Fragment ; MUC6 mucin ; MUC6 mucin Fragment ; MUC6_HUMAN ; Mucin 6 ; Mucin 6 gastric ; Mucin 6 oligomeric mucus/gel forming ; Mucin glycoprotein Fragment ; Mucin-6 ; Secretory mucin MUC6 Fragment .
Research Area	Tumour  Cell biology  Cytoskeleton  Extracellular matrix
Immunogen Species	Mouse
Clonality	Monoclonal
Clone NO.	6H8
React Species	Human,
Applications	IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	298kDa
Cellular localization	Secretory protein
Form	Liquid
immunogen	KLH conjugated synthetic peptide derived from human MUC6
Lsotype	IgG2a
Purification	affinity purified by Protein G
Buffer Solution	0.01M PBS(pH7.4) with 1% BSA and 0.1% Proclin300
Storage	Store at 2-8 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	This gene encodes a member of the mucin protein family. Mucins are high molecular weight glycoproteins produced by many epithelial tissues. The protein encoded by this gene is secreted and forms an insoluble mucous barrier that protects the gut lumen. [provided by RefSeq, Dec 2016] Function: May provide a mechanism for modulation of the composition of the protective mucus layer related to acid secretion or the presence of bacteria and noxious agents in the lumen. Play an important role in the cytoprotection of epithelial surfaces and are used as tumor markers in a variety of cancers. May play a role in epithelial organogenesis. Subcellular Location: Secreted. Tissue Specificity: Expressed in the regenerative zone of gastric antrum, gastric body mucosa and gastric incisura mucosa. Expressed in the deeper mucous glands of gastric antrum. Overexpressed in Helicobacter pylori infected gastric epithelium. Highly expressed in duodenal Brunner's glands, gall bladder, seminal vesicle, pancreatic centroacinar cells and ducts, and periductal glands of the common bile duct. Post-translational modifications: O-glycosylated. Similarity: Contains 1 CTCK (C-terminal cystine knot-like) domain. Contains 1 TIL (trypsin inhibitory-like) domain. Contains 3 VWFD domains. SWISS: Q6W4X9 Gene ID: 4588 Database links: Entrez Gene: 4588 Human Entrez Gene: 353328 Mouse Entrez Gene: 282586 Rat Omim: 158374 Human SwissProt: Q6W4X9 Human SwissProt: Q80T03 Mouse Unigene: 528432 Human Unigene: 246621 Mouse Unigene: 92457 Rat
Product Picture	Paraformaldehyde-fixed, paraffin embedded (human gastric); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (MUC6) Monoclonal Antibody, Unconjugated (BH0156) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Mouse)(sp-0024) instructionsand DAB staining. araformaldehyde-fixed, paraffin embedded (human gastric carcinoma); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (MUC6) Monoclonal Antibody, Unconjugated (BH0156) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Mouse)(sp-0024) instructionsand DAB staining. Paraformaldehyde-fixed, paraffin embedded (human gastric); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (MUC6) Monoclonal Antibody, Unconjugated (BH0156) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Mouse)(sp-0024) instructionsand DAB staining.

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