Product Name	Anti-HAP1/RBITC
Chinese Name	罗丹明（RBITC）标记的舞蹈症相关蛋白1抗体
Alias	Huntingtin Associated Protein 1; HAP 1; HAP 2; HAP-1; Hap1; HAP1_HUMAN; HAP2; HAPP; hHAP1; hHLP1; HIP 5; HIP5; HLP; HLP1; Huntingtin-associated protein 1; huntingtin-associated protein 2; Neuroan 1; Neuroan1.
Research Area	Cell biology  Neurobiology  Signal transduction
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Rat,  (predicted: Human, Mouse, Rabbit, )
Applications	ICC=1:50-200 IF=1:50-200  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Molecular weight	75kDa
Form	Lyophilized or Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human HAP1
Lsotype	IgG
Purification	affinity purified by Protein A
Storage Buffer	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Product Detail	background: Huntingtin-associated protein 1 binds to Huntingtin. Huntingtin is a protein that contains a polyglutamine region and when the number of glutamine repeats exceeds 35, the gene encodes a version of Huntingtin that leads to Huntington’s disease (HD). The ability of HAP1 to bind to Huntingtin is enhanced by an expanded polyglutamine repeat region. HAP1 shows neuronal localization and moves with Huntingtin in nerve fibers. HAP1 is primarily expressed in brain tissue, with greater expression in the olfactory bulb and brain stem. HAP1 in rat has been shown to associate with a number of intracellular organelles. Mouse HAP1 is localized to membrane-bound organelles including large endosomes, tubulovesicular structures and budding vesicles in neurons. Function: Associates specifically with huntingtin. This binding is enhanced by an expanded polyglutamine repeat. Tissue Specificity: Predominantly expressed in brain. Selectively expressed in neurons. Similarity: Contains 1 HAP1 N-terminal domain. Database links: Entrez Gene: 9001 Human Entrez Gene: 15114 Mouse Entrez Gene: 29430 Rat Omim: 600947 Human SwissProt: P54257 Human SwissProt: O35668 Mouse SwissProt: P54256 Rat Unigene: 158300 Human Unigene: 281700 Mouse Unigene: 37430 Rat   Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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