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Product Name Anti-Plexin D1/RBITC Chinese Name 罗丹明(RBITC)标记的神经丛蛋白D1抗体 Alias KIAA0620; MGC75353; PLEX D1; PLEXD 1; PLEXD1; Plexin-D1; PlexinD1; PLXD1_HUMAN; PLXN D1; PLXND 1; PLXND1; PLXND1 protein. Research Area Cardiovascular Cell biology Neurobiology Signal transduction Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Mouse, Rat, Dog, Pig, Cow, Rabbit, ) Applications ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Molecular weight 208kDa Form Lyophilized or Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human Plexin D1 Lsotype IgG Purification affinity purified by Protein A Storage Buffer 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. Product Detail Function:
Cell surface receptor for SEMA4A and for class 3 semaphorins, such as SEMA3A, SEMA3C and SEMA3E. Plays an important role in cell-cell signaling, and in regulating the migration of a wide spectrum of cell types. Regulates the migration of thymocytes in the medulla. Regulates endothelial cell migration. Plays an important role in ensuring the specificity of synapse formation. Required for normal development of the heart and vasculature (By similarity). Mediates anti-angiogenic signaling in response to SEMA3E.
Subunit:
Interacts with NRP1, SEMA4A, SEMA3A, SEMA3C and SEMA3E.
Subcellular Location:
Cell membrane.
Tissue Specificity:
Detected at low levels in heart, placenta, lung, skeletal muscle, kidney, thymus and liver. Detected at very low levels in brain, colon, spleen, small intestine and peripheral blood leukocytes.
Similarity:
Belongs to the plexin family.
Contains 3 IPT/TIG domains.
Contains 1 Sema domain.
Database links:Entrez Gene: 23129 Human
Entrez Gene: 67784 Mouse
Omim: 604282 Human
SwissProt: Q9Y4D7 Human
SwissProt: Q3UH93 Mouse
SwissProt: Q68HV1 Mouse
SwissProt: Q8VCL8 Mouse
SwissProt: Q9CZF2 Mouse
Unigene: 301685 Human
Unigene: 3085 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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