Product Name	Anti-OBFC1/RBITC
Chinese Name	罗丹明（RBITC）标记的α辅助因子44抗体
Alias	AAF 44; AAF44; Alpha accessory factor 44; bA541N10.2; CST complex subunit STN1; FLJ22559; Obfc1; Oligonucleotide/oligosaccharide binding fold containing 1; Oligonucleotide/oligosaccharide-binding fold-containing protein 1; OTTHUMP00000020417; OTTHUMP00000020418; Replication protein A 32 kDa subunit; RP11-541N10.2; RPA 32; STN1; STN1_HUMAN; Suppressor of cdc thirteen; Suppressor of cdc thirteen homolog.
Research Area	Binding protein  Epigenetics
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Horse, )
Applications	ICC=1:50-200 IF=1:50-200  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Molecular weight	42kDa
Form	Lyophilized or Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human OBFC1/AAF44
Lsotype	IgG
Purification	affinity purified by Protein A
Storage Buffer	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Product Detail	background: OBFC1 and C17ORF68 (MIM 613129) are subunits of an alpha accessory factor (AAF) that stimulates the activity of DNA polymerase-alpha-primase (see MIM 176636), the enzyme that initiates DNA replication (Casteel et al., 2009 [PubMed 19119139]). OBFC1 also appears to function in a telomere-associated complex with C17ORF68 and TEN1 (C17ORF106; MIM 613130) (Miyake et al., 2009 [PubMed 19854130]).[supplied by OMIM, Nov 2009] Function: Component of the CST complex, a complex that binds to single-stranded DNA and is required to protect telomeres from DNA degradation. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. In addition to telomere protection, the CST complex has probably a more general role in DNA metabolism at non-telomeric sites. Subcellular Location: Nucleus. Chromosome > telomere. Similarity: Belongs to the STN1 family. Contains 1 OB DNA-binding domain. Database links: Entrez Gene: 79991 Human Entrez Gene: 108689 Mouse Omim: 613128 Human SwissProt: Q9H668 Human SwissProt: Q8K2X3 Mouse Unigene: 62314 Human Unigene: 218048 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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