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Rabbit Anti-ZHX3/RBITC Conjugated antibody
Rabbit Anti-ZHX3/RBITC Conjugated antibody
KIAA0395; TIX1; Triple homeobox 1; Triple homeobox protein 1; ZHX 3; Zhx3; ZHX3_HUMAN; Zinc finger and homeodomain protein 3; Zinc fingers and homeoboxes protein 3.
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Details

Product Name Anti-ZHX3/RBITC
Chinese Name 罗丹明(RBITC)标记的同源三聚体Zinc finger proteinZHX3抗体
Alias KIAA0395; TIX1; Triple homeobox 1; Triple homeobox protein 1; ZHX 3; Zhx3; ZHX3_HUMAN; Zinc finger and homeodomain protein 3; Zinc fingers and homeoboxes protein 3.  
Research Area Developmental biology  transcriptional regulatory factor  Zinc finger protein  Epigenetics  
Immunogen Species Rabbit
Clonality Polyclonal
React Species (predicted: Human, Rabbit, )
Applications ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
Molecular weight 105kDa
Form Lyophilized or Liquid
Concentration 1mg/ml
immunogen KLH conjugated synthetic peptide derived from human ZHX3
Lsotype IgG
Purification affinity purified by Protein A
Storage Buffer 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Product Detail background:
This gene encodes a member of the zinc fingers and homeoboxes (ZHX) gene family. The encoded protein contains two C2H2-type zinc fingers and five homeodomains and forms a dimer with itself or with zinc fingers and homeoboxes family member 1. In the nucleus, the dimerized protein interacts with the A subunit of the ubiquitous transcription factor nuclear factor-Y and may function as a transcriptional repressor. [provided by RefSeq, Jul 2008]

Function:
Acts as a transcriptional repressor. Involved in the early stages of mesenchymal stem cell (MSC) osteogenic differentiation. Is a regulator of podocyte gene expression during primary glomerula disease. Binds to promoter DNA.

Subcellular Location:
Nucleus.

Tissue Specificity:
Widely expressed. High expression in kidney.

Similarity:
Belongs to the ZHX family.
Contains 2 C2H2-type zinc fingers.
Contains 5 homeobox DNA-binding domains.

Database links:

Entrez Gene: 23051 Human

Omim: 609598 Human

SwissProt: Q9H4I2 Human

Unigene: 380133 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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