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Product Name Anti-CHST5/RBITC Chinese Name 罗丹明(RBITC)标记的碳水化合物磺基转移酶5抗体 Alias Carbohydrate (N acetylglucosamine 6 O) sulfotransferase 5; Carbohydrate sulfotransferase 5; Chst5; CHST5_HUMAN; FLJ22167; Galactose/N acetylglucosamine/N acetylglucosamine 6 O sulfotransferase 4 alpha; Galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 4-alpha; GlcNAc6ST 3; GlcNAc6ST-3; Gn6st-3; GST4 alpha; GST4-alpha; Intestinal GlcNAc-6-sulfotransferase; N acetylglucosamine 6 O sulfotransferase 3. Research Area Cell biology Signal transduction The new supersedes the old Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep, ) Applications ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Molecular weight 46kDa Form Lyophilized or Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human CHST5 Lsotype IgG Purification affinity purified by Protein A Storage Buffer 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. Product Detail background:
The protein encoded by this gene belongs to the Gal/GalNAc/GlcNAc 6-O-sulfotransferase (GST) family, members of which catalyze the transfer of sulfate to position 6 of galactose (Gal), N-acetylgalactosamine (GalNAc), or N-acetylglucosamine (GlcNAc) residues within proteoglycans, and sulfation of O-linked sugars of mucin-type acceptors. Carbohydrate sulfation plays a critical role in many biologic processes. This gene is predominantly expressed in colon and small intestine. [provided by RefSeq, Aug 2011]
Function:
Catalyzes the transfer of sulfate to position 6 of non-reducing N-acetylglucosamine (GlcNAc) residues and O-linked sugars of mucin-type acceptors. Acts on the non-reducing terminal GlcNAc of short carbohydrate substrates. However, it does not transfer sulfate to longer carbohydrate substrates that have poly-N-acetyllactosamine structures. Has no activity toward keratan. Not involved in generating HEV-expressed ligands for L-selectin. Its substrate specificity may be influenced by its subcellular location.
Subcellular Location:
Golgi apparatus membrane. Golgi membrane, early secretory pathway.
Tissue Specificity:
Predominantly expressed in small and large intestines and colon. Weakly expressed in lymphocytes. Not expressed in other tissues. Down-regulated in colonic adenocarcinomas.
Similarity:
Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily.
Database links:Entrez Gene: 23563 Human Omim: 604817 Human SwissProt: Q9GZS9 Human Unigene: 156784 Human Unigene: 710689 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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