Product Name	Anti-SCUBE2/RBITC
Chinese Name	罗丹明（RBITC）标记的内皮分泌蛋白SCUBE2抗体
Alias	4932442O19Rik; Cegb1; Cegf1; CEGP1; Cegp1 protein; CUB domain and EGF-like repeat containing 1; FLJ16792; FLJ35234; ICRFP703B1614Q5.1; MGC133057; Protein CEGP1; RGD1563998; SCUB2_HUMAN; Scube2; Signal peptide, CUB and EGF-like domain-containing protein 2; Signal peptide, CUB domain, EGF-like 2.
Research Area	Tumour  Cell biology  immunology  Neurobiology  Stem cells  vascular endothelial cell  endothelial cells
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Chicken, Dog, Horse, Rabbit, )
Applications	ICC=1:50-200 IF=1:50-200  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Molecular weight	107kDa
Form	Lyophilized or Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from Human SCUBE2
Lsotype	IgG
Purification	affinity purified by Protein A
Storage Buffer	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Product Detail	background: SCUBE2 is a 999 amino acid protein that is ubiquitously expressed in adult tissues and belongs to the evolutionarily conserved SCUBE protein family. Containing a CUB domain and nine EGF-like domains, SCUBE2 manifests as a secreted surface-anchored glycoprotein when overexpressed and is considered a novel component of the HH (Hedgehog) signal. The HH signal plays a pivotal role in induction of ventral neuronal and muscle cell types around the midline during vertebrate development. It is suggested that SCUBE2 expression is important in breast cancer progression and may serve as a useful prognostic marker. SCUBE2 forms homo-oligomers and hetero-oligomers with SCUBE1 and SCUBE3. Expressed as three isoforms produced by alternative splicing events, SCUBE2 is encoded by a gene located on human chromosome 11, which houses over 1,400 genes and comprises nearly 4% of the human genome. Subunit: Forms homooligomers and heterooligomers with SCUBE1 and SCUBE3 (By similarity). Subcellular Location: Secreted. Tissue Specificity: Expressed in a broad spectrum of adult tissues. Similarity: Contains 1 CUB domain. Contains 9 EGF-like domains. Database links: Entrez Gene: 57758 Human Entrez Gene: 56788 Mouse Omim: 611747 Human SwissProt: Q9NQ36 Human SwissProt: Q9JJS0 Mouse Unigene: 523468 Human Unigene: 40447 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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