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Product Name Anti-Chromogranin C/RBITC Chinese Name 罗丹明(RBITC)标记的嗜铬粒蛋白C抗体 Alias CHGC; Chromogranin-C; MEN1; SCG2; SCG2_HUMAN; Secretogranin II; Secretogranin-2; Secretoneurin; Secretoneurin included; SgII; SN. Research Area Cell biology Neurobiology Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Mouse, Rat, Dog, Horse, ) Applications ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Molecular weight 68kDa Form Lyophilized or Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human Chromogranin C/Sg II (101-200aa) Lsotype IgG Purification affinity purified by Protein A Storage Buffer 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. Product Detail background:
Chromogranins (secretogranins) are acidic glycoproteins that localize within secretory granules of endocrine, neuroendocrine and neuronal tissue. Family members include chromogranin A (Chr-A); chromogranin B (Chr-B), also known as secretogranin I; chromogranin C (also known as secretogranin II or Sg II); and secretogranin III (Sg III or SCG3). High levels of Chr-A expression are characteristic of neuroendocrine tumors. Pancreastatin is a peptide derived from Chr-A which inhibits insulin secretion, exocrine pancreatic secretion and gastric acid secretion. Pancreastatin exists as two forms; the major form is expressed in stomach and colon extracts. In neuroendocrine cells the level Sg II has been shown to increase four-fold in response to histamine, while levels of Chr-A and Chr-B showed little or no increase. Sg III is an acidic secretory protein expressed in neuronal and endocrine cells. In the anterior lobe of the rat pituitary gland, Sg III is present in mammotropes and thyrotropes, moderately in gonadotropes and corticotropes, though not in somatotropes. Sg III and carboxypeptidase E (CPE) bind specifically to cholesterol-rich secretory granule (SG) membranes.
Function:
Secretogranin-2 is a neuroendocrine secretory granule protein, which is the precursor for biologically active peptides.
Subcellular Location:
Secreted. Neuroendocrine and endocrine secretory granules.
Tissue Specificity:
Belongs to the chromogranin/secretogranin protein family.
Similarity:
Belongs to the chromogranin/secretogranin protein family.
Database links:Entrez Gene: 7857 Human
Entrez Gene: 20254 Mouse
Omim: 118930 Human
SwissProt: P13521 Human
SwissProt: Q03517 Mouse
Unigene: 516726 Human
Unigene: 5038 Mouse
Unigene: 45602 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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