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Rabbit Anti-GPM6B/RBITC Conjugated antibody
Rabbit Anti-GPM6B/RBITC Conjugated antibody
M6b; Neuronal membrane glycoprotein M6b; rhombex 29; GPM6B_HUMAN.
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Product Name Anti-GPM6B/RBITC
Chinese Name 罗丹明(RBITC)标记的神经The cell membraneglycoproteinM6b
Alias M6b; Neuronal membrane glycoprotein M6b; rhombex 29; GPM6B_HUMAN.  
Research Area Cell biology  Developmental biology  Neurobiology  Signal transduction  
Immunogen Species Rabbit
Clonality Polyclonal
React Species Mouse, Rat,  (predicted: Human, Pig, Horse, )
Applications ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
Molecular weight 29kDa
Form Lyophilized or Liquid
Concentration 1mg/ml
immunogen KLH conjugated synthetic peptide derived from human GPM6B
Lsotype IgG
Purification affinity purified by Protein A
Storage Buffer 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Product Detail background:
GPM6B belongs to the myelin proteolipid protein family and is implicated in neural development. It is expressed in neurons and glia; cerebellar Bergmann glia, in glia within white matter tracts of the cerebellum and cerebrum, and in embryonic dorsal root ganglia.

Function:
May be involved in neural development. Involved in regulation of osteoblast function and bone formation. Involved in matrix vesicle release by osteoblasts; this function seems to involve maintenance of the actin cytoskeleton. May be involved in cellular trafficking of SERT and thereby in regulation of serotonin uptake.

Subunit:
Interacts with SERT.

Subcellular Location:
Cell membrane; Multi-pass membrane protein (By similarity). Note=Colocalizes with SERT at the plasma membrane

Tissue Specificity:
Neurons and glia; cerebellar Bergmann glia, in glia within white matter tracts of the cerebellum and cerebrum, and in embryonic dorsal root ganglia.

Similarity:
Belongs to the myelin proteolipid protein family.

Database links:

Entrez Gene: 2824 Human

Entrez Gene: 14758 Mouse

Entrez Gene: 192179 Rat

Omim: 300051 Human

SwissProt: Q13491 Human

SwissProt: P35803 Mouse

SwissProt: Q9JJK1 Rat

Unigene: 495710 Human

Unigene: 222320 Mouse

Unigene: 153513 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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