Product Name	Anti-DOCK7/RBITC
Chinese Name	罗丹明（RBITC）标记的胞质分裂专一蛋白7抗体
Alias	dedicator of cytokinesis 7; Dedicator of cytokinesis protein 7; Gm430; KIAA1771 ; MGC189434; mKIAA1771; RP23 329P19.2; ZIR2; DOCK7_HUMAN.
Research Area	Cell biology  Neurobiology  Signal transduction  G protein-coupled receptor  G protein signal
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Chicken, Dog, Cow, Horse, Rabbit, Sheep, )
Applications	IF=1:50-200  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Molecular weight	242kDa
Form	Lyophilized or Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human DOCK7
Lsotype	IgG
Purification	affinity purified by Protein A
Storage Buffer	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Product Detail	background: DOCK 7 is a 2,140 amino acid protein that localizes to developing axons and contains one DHR-1 domain and one DHR-2 domain. Expressed in a variety of tissues, DOCK 7 functions as a guanine nucleotide exchange factor (GEF) that specifically activates Rac 1 and Rac 3 by catalyzing the exchange of bound GDP for free GTP. Multiple isoforms of DOCK 7 exist due to alternative splicing events. Function: DOCK7 functions as a guanine nucleotide exchange factor (GEF), which activates Rac1 and Rac3 Rho small GTPases by exchanging bound GDP for free GTP. It does not have a GEF activity for CDC42. It is required for STMN1 'Ser-15' phosphorylation during axon formation and consequently for neuronal polarization. Subunit: Interacts with TSC1. Interacts with nucleotide-free RAC1 and RAC3. Subcellular Location: Cell projection, Tissue Specificity: Widely expressed. Similarity: Belongs to the DOCK family. Contains 1 DHR-1 domain. Contains 1 DHR-2 domain. Database links: Entrez Gene: 85440 Human GenBank: BC016392.1 Human SwissProt: Q96N67 Human Unigene: 406156 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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