Product Name	Anti-TBX2/RBITC
Chinese Name	罗丹明（RBITC）标记的新型抑癌基因抗体
Alias	T-bet; T-box2; T-box Protein 2; T-box transcription factor TBX2; T-box protein 2; FLJ10169; HGNC: 11597; T box 2; T box transcription factor TBX2; TBX2; TBX2_HUMAN.
Research Area	Tumour  Cell biology  Signal transduction  Apoptosis
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Rat,  (predicted: Human, Mouse, )
Applications	IF=1:50-200  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Molecular weight	74kDa
Form	Lyophilized or Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human TBX2
Lsotype	IgG
Purification	affinity purified by Protein A
Storage Buffer	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Product Detail	background: This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene product is the human homolog of mouse Tbx2, and shares strong sequence similarity with Drosophila omb protein. Expression studies indicate that this gene may have a potential role in tumorigenesis as an immortalizing agent. Transcript heterogeneity due to alternative polyadenylation has been noted for this gene. Function: Involved in the transcriptional regulation of genes required for mesoderm differentiation. Probably plays a role in limb pattern formation. Acts as a negative regulator of PML function in cellular senescence. Subunit: Interacts with PML (isoform-PML-2, isoform PML-3 and isoform PML-4). Subcellular Location: Nucleus. Tissue Specificity: Expressed primarily in adult in kidney, lung, and placenta. Weak expression in heart and ovary. Similarity: Contains 1 T-box DNA-binding domain. Database links: Entrez Gene: 6909 Human Entrez Gene: 21385 Mouse Omim: 600747 Human SwissProt: Q13207 Human SwissProt: Q60707 Mouse Unigene: 531085 Human Unigene: 287052 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 经研究发现，在人黑色素瘤及很多恶性Tumour组织中普遍存在TBX2基因表达的增高,该蛋白与恶性Tumour的发生、发展密切相关.TBX2基因被认为是一种新发现的抑癌基因。

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