Product Name	Anti-ICAD/RBITC
Chinese Name	罗丹明（RBITC）标记的Caspase激活的脱氧核糖核酸酶抑制剂抗体
Alias	DFF-45 Beta; ICAD; ICAD L; ICAD S; Caspase activated deoxyribonuclease inhibitor short form; DFF 1; DFF 45; DFF-45; DFF alpha; DFF1; DFF35; DFF45; DFFA; Dffa DNA fragmentation factor, alpha subunit; DNA fragmentation factor 45 kDa subunit; DNA Fragmentation Factor Alpha Subunit; DNA fragmentation factor subunit alpha; DNA fragmentation factor, 45 kD, alpha subunit; DNA fragmentation factor, 45kDa, alpha polypeptide (DFFA), transcript variant 1; A330085O09Rik; DNA fragmentation factor, 45kDa, alpha polypeptide; DNA fragmentation factor, alpha subunit; H13; Inhibitor of CAD; DFFA_HUMAN; Inhibitor of CAD; Inhibitor of Caspase Activated DNase; MGC143066; OTTHUMP00000001903; OTTHUMP00000001904; RP23 121D17.3;Inhibitor of Caspase Activated DNase.
Research Area	Cell biology  immunology  Chromatin and nuclear signals  Apoptosis  The new supersedes the old  Epigenetics
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human, Mouse, Rat,
Applications	IF=1:50-200  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Molecular weight	36kDa
Form	Lyophilized or Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human ICAD
Lsotype	IgG
Purification	affinity purified by Protein A
Storage Buffer	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Product Detail	background: Caspase-activated deoxyribonuclease(CAD) also designated DNA fragmentation factor 45 kDa subunit (DFF-45)and Caspase-activated DNase. CAD is a nuclease that induces DNA fragmentation and chromatin condensation during apoptosis. Degrades naked DNA and induces apoptotic morphology. ICAD (DNA fragmentation factor alpha subunit) (DNA fragmentation factor 45 kDa subunit) (DFF-45) (Inhibitor of CAD) is inhibitor of the caspase-activated DNase (DFF44). Function: Inhibitor of the caspase-activated DNase (DFF40). Subunit: Heterodimer of DFFA and DFFB. Subcellular Location: Cytoplasm. Post-translational modifications: Caspase-3 cleaves DFF45 at 2 sites to generate an active factor. Similarity: Contains 1 CIDE-N domain. Database links: Entrez Gene: 1676 Human Omim: 601882 Human SwissProt: O00273 Human Unigene: 484782 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. ICAD 是在Apoptosis期诱导DNA分裂和染色体固缩的一种核酶，降解裸露的DNA 并诱导形态学变化。

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