Product Name	Anti-NR2D/RBITC
Chinese Name	罗丹明（RBITC）标记的谷氨酸受体2D抗体
Alias	Glutamate [NMDA] receptor subunit epsilon 4; Grin2d; N-methyl D-aspartate receptor subtype 2D; NMDAR2D; NMDE4; NR2D; NMDE4_HUMAN; Glutamate [NMDA] receptor subunit epsilon-4; EB11.
Research Area	Neurobiology
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human,  (predicted: Mouse, Rat, Dog, Pig, Cow, )
Applications	ICC=1:50-200 IF=1:50-200  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Molecular weight	143kDa
Form	Lyophilized or Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human NR2D
Lsotype	IgG
Purification	affinity purified by Protein A
Storage Buffer	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Product Detail	background: NR2D is a NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. NR2D is expressed in the brain; it is detected in embryonic stages, peaks at postnatal day 7, and decreases thereafter to adult levels. [FUNCTION] NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. [SUBUNIT] Forms heteromeric channel of a zeta subunit (GRIN1), a epsilon subunit (GRIN2A, GRIN2B, GRIN2C or GRIN2D) and a third subunit (GRIN3A or GRIN3B). Interacts with PDZ domains of INADL and DLG4. [SUBCELLULAR LOCATION] Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. [TISSUE SPECIFICITY] Expressed in brain, mainly in the subcortical region. [SIMILARITY] Belongs to the glutamate-gated ion channel. Subunit: Interacts with PDZ domains of INADL and DLG4 (By similarity). Forms heteromeric channel of a zeta subunit (GRIN1), a epsilon subunit (GRIN2A, GRIN2B, GRIN2C or GRIN2D) and a third subunit (GRIN3A or GRIN3B). Subcellular Location: Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Similarity: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. NR2D/GRIN2D subfamily. Database links: Entrez Gene: 2906 Human Entrez Gene: 14814 Mouse Entrez Gene: 24412 Rat Omim: 602717 Human SwissProt: O15399 Human SwissProt: Q03391 Mouse SwissProt: Q62645 Rat Unigene: 445015 Human Unigene: 91209 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 谷氨酸受体2D（NR2D 又称作Glutamate Receptor NMDAR2D;Glutamate receptor；N-Methyl-d-Asprtate receptor-2D）是脊椎动物中枢神经系统兴奋型神经传递的主要介质。在突触可塑性极大脑学习及记忆功能方面起关键作用。

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