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Product Name Anti-SLC15A2/RBITC Chinese Name 罗丹明(RBITC)标记的肠道肽Transporter2抗体 Alias Peptide-transporters 2; solute carrier family 15 (H+/peptide transporter), member 2; 8430408C16Rik; C78862; FLJ33407; MGC91625; PEPT2; SLC15A2; S15A2_HUMAN. Research Area Transporter Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Mouse, Rat, ) Applications IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Molecular weight 81kDa Form Lyophilized or Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human PEPT2 C-terminus Lsotype IgG Purification affinity purified by Protein A Storage Buffer 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. Product Detail background:
The mammalian kidney expresses a proton-coupled peptide transporter that is responsible for the absorption of small peptides, as well as beta-lactam antibiotics and other peptide-like drugs, from the tubular filtrate. This transporter, SLC15A2, belongs to the same gene family as SLC15A1 (MIM 600544), the proton-coupled peptide transporter found in the small intestine (Liu et al, 1995 [PubMed 7756356]).[supplied by OMIM, Feb 2011]
Function:
Proton-coupled intake of oligopeptides of 2 to 4 amino acids with a preference for dipeptides.
Subcellular Location:
Membrane; Multi-pass membrane protein.
Similarity:
Belongs to the PTR2/POT transporter (TC 2.A.17) family.
Database links:Entrez Gene: 6565 Human
Omim: 602339 Human
SwissProt: Q16348 Human
Unigene: 518089 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
小肽转运载体主要有2种:PepT1(SLC15A1)和PepT2(SLC15A2)。
PepT1主要在小肠中表达,对小肽的吸收起关键性作用,它能转运2~5个氨基酸残基的肽,但以转运二肽的速度最快,而PepT2主要在肾中表达,对小肽起重新吸收的作用.<
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