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Product Name Anti-DNAJC3/RBITC Chinese Name 罗丹明(RBITC)标记的Interferon诱导蛋白p58ipk抗体 Alias DNAJC3; p58ipk; Protein Kinase Inhibitor P58; DnaJ homolog subfamily C member 3; HP58; Interferon induced, double stranded RNA activated protein kinase inhibitor; P58; p58 ipk ; P58IPK; PRKRI; Protein kinase inhibitor of 58 kDa; Protein kinase inhibitor p58; DNJC3_HUMAN. Research Area Cell biology Signal transduction Epigenetics Immunogen Species Rabbit Clonality Polyclonal React Species Rat, (predicted: Human, Mouse, Dog, Pig, Cow, Horse, ) Applications IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Molecular weight 55kDa Form Lyophilized or Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human p58ipk Lsotype IgG Purification affinity purified by Protein A Storage Buffer 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. Product Detail background:
DNAJC3 may act as an inhibitor of both the autophosphorylation of EIF2AK2/PKR and the ability of EIF2AK2/PKR to catalyze phosphorylation of the EIF2A. It also functions as a Co-chaperone of HSPA8/HSC70 and is involved in the unfolded protein response (UPR) during ER stress. It has been reported that this protein stimulates the ATPase activity of HSPA8/HSC70.DNAJC3 is also involved in ativiral defense - it is activated in response to infection by influenza virus through the dissociation of DNAJB1. DNAJC3 is widely expressed and can be found at high levels in the testis and pancreas (expression in cell lines is variable).
Function:
Involved in the unfolded protein response (UPR) during ER stress. Co-chaperone of HSPA8/HSC70, it stimulates its ATPase activity. May inhibit both the autophosphorylation of EIF2AK2/PKR and the ability of EIF2AK2 to catalyze phosphorylation of the EIF2A. May inhibit EIF2AK3/PERK activity.
Subcellular Location:
Endoplasmic reticulum.
Tissue Specificity:
Widely expressed with high level in the pancreas and testis. Also expressed in cell lines with different levels.
Similarity:
Contains 1 J domain.
Contains 9 TPR repeats.
Database links:Entrez Gene: 5611 Human
Entrez Gene: 100037258 Mouse
Omim: 601184 Human
SwissProt: Q13217 Human
SwissProt: Q91YW3 Mouse
Unigene: 59214 Human
Unigene: 12616 Mouse
Unigene: 162234 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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