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Product Name Anti-CD93/RBITC Chinese Name 罗丹明(RBITC)标记的CD93抗体 Alias C1qrp; Complement component C1q receptor; C1q/MBL/SPA receptor; C1qR(p); C1qr1; C1qRp; CD93 antigen; CD93 molecule; CDw93; Complement component 1 q subcomponent receptor 1; Complement component C1q receptor; dJ737E23.1; ECSM3; Ly68; Matrix remodeling associated protein 4; MXRA4. Research Area immunology Cell adhesion molecule Cell Surface Molecule glycoprotein Cell type markers Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Mouse, Rat, Pig, Cow, Horse, Rabbit, Sheep, ) Applications
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Molecular weight 70kDa Form Lyophilized or Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human CD93 Lsotype IgG Purification affinity purified by Protein A Storage Buffer 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. Product Detail background:
The protein encoded by this gene is a cell-surface glycoprotein and type I membrane protein that was originally identified as a myeloid cell-specific marker. The encoded protein was once thought to be a receptor for C1q, but now is thought to instead be involved in intercellular adhesion and in the clearance of apoptotic cells. The intracellular cytoplasmic tail of this protein has been found to interact with moesin, a protein known to play a role in linking transmembrane proteins to the cytoskeleton and in the remodelling of the cytoskeleton. [provided by RefSeq, Jul 2008].
Function:
Receptor (or element of a larger receptor complex) for C1q, mannose-binding lectin (MBL2) and pulmonary surfactant protein A (SPA). May mediate the enhancement of phagocytosis in monocytes and macrophages upon interaction with soluble defense collagens. May play a role in intercellular adhesion.
Subunit:
Interacts with HCV core protein. Interacts with C1QBP; the association may represent a cell surface C1q receptor.
Subcellular Location:
Membrane; Single-pass type I membrane protein.
Tissue Specificity:
Highly expressed in endothelial cells, platelets, cells of myeloid origin, such as monocytes and neutrophils. Not expressed in cells of lymphoid origin.
Post-translational modifications:
N- and O-glycosylated.
Similarity:
Contains 1 C-type lectin domain.
Contains 5 EGF-like domains.
Database links:Entrez Gene: 22918 Human
Entrez Gene: 17064 Mouse
Omim: 120577 Human
SwissProt: Q9NPY3 Human
SwissProt: O89103 Mouse
Unigene: 97199 Human
Unigene: 681 Mouse
Unigene: 162695 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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