Product Name	Anti-SPHK1/RBITC
Chinese Name	罗丹明（RBITC）标记的鞘氨醇激酶1抗体
Alias	sphingosine kinase 1; SK 1; SK1; SPHK 1; SPHK; SPK; SPK 1; SPK1; Sphk1; SPHK1_HUMAN.
Research Area	Tumour  Cell biology  Signal transduction  Apoptosis  Kinases and Phosphatases  Cell differentiation
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Mouse,  (predicted: Human, Rat, Dog, Cow, Rabbit, )
Applications	IF=1:50-200  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Molecular weight	42-52kDa
Form	Lyophilized or Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human SPHK1
Lsotype	IgG
Purification	affinity purified by Protein A
Storage Buffer	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Product Detail	background: The protein encoded by this gene catalyzes the phosphorylation of sphingosine to form sphingosine-1-phosphate (S1P), a lipid mediator with both intra- and extracellular functions. Intracellularly, S1P regulates proliferation and survival, and extracellularly, it is a ligand for cell surface G protein-coupled receptors. This protein, and its product S1P, play a key role in TNF-alpha signaling and the NF-kappa-B activation pathway important in inflammatory, antiapoptotic, and immune processes. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011] Function: Catalyzes the phosphorylation of sphingosine to form sphingosine 1-phosphate (SPP), a lipid mediator with both intra-and extracellular functions. Also acts on D-erythro-sphingosine and to a lesser extent sphinganine, but not other lipids, such as D,L-threo-dihydrosphingosine, N,N-dimethylsphingosine, diacylglycerol, ceramide, or phosphatidylinositol. Tissue Specificity: Widely expressed with highest levels in adult liver, kidney, heart and skeletal muscle. Similarity: Contains 1 DAGKc domain. Database links: Entrez Gene: 8877 Human Entrez Gene: 20698 Mouse Entrez Gene: 170897 Rat Omim: 603730 Human SwissProt: Q9NYA1 Human SwissProt: Q8CI15 Mouse SwissProt: Q91V26 Rat Unigene: 68061 Human Unigene: 20944 Mouse Unigene: 18522 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. SPHK1参与鞘氨醇代谢、G protein-coupled receptor蛋白Signal transduction途径，有抗Apoptosis的作用，可被蛋白激酶C激活，参与细胞内Signal transduction级联、钙介导Signal transduction、调控细胞生长迁移、调控血管生成及成纤维细胞增殖。

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