Product Name	Anti-MYL3/RBITC
Chinese Name	罗丹明（RBITC）标记的肌球蛋白轻链3抗体
Alias	Cardiac myosin light chain 1; Slow skeletal Myosin; CMH8; CMLC1; MLC1SB; MLC1V; MYL3; MYL3_HUMAN; Myosin light chain 1; Myosin light chain 1 slow twitch muscle B ventricular isoform; myosin light chain 3 alkali ventricular skeletal slow; Myosin light chain 3; slow-twitch muscle B/ventricular isoform; Ventricular slow twitch myosin alkali light chain; Ventricular/slow twitch myosin alkali light chain; VLC1.
Research Area	Cardiovascular  immunology
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Mouse,  (predicted: Human, Rat, Chicken, Dog, Pig, Cow, Rabbit, )
Applications	IF=1:50-200  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Molecular weight	22kDa
Form	Lyophilized or Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human MLC/Myosin light chain 3
Lsotype	IgG
Purification	affinity purified by Protein A
Storage Buffer	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Product Detail	background: Myosin is the major component of thick muscle filaments, and is a long asymmetric molecule containing a globular head and a long tail. The molecule consists of two heavy chains each ~200,000 daltons, and four light chains each ~16,000 - 21,000 daltons. Activation of smooth and cardiac muscle primarily involves pathways which increase calcium and myosin phosphorylation resulting in contraction. Myosin light chain phosphatase acts to regulate muscle contraction by dephosphorylating activated myosin light chain. Human myosin light chain has clinical application as a cardiac marker. Function: Regulatory light chain of myosin. Does not bind calcium. Subunit: Myosin is a hexamer of 2 heavy chains and 4 light chains. Post-translational modifications: The N-terminus is blocked. N-terminus is methylated by METTL11A/NTM1. DISEASE: Cardiomyopathy, familial hypertrophic 8 (CMH8)[MIM:608751]: A hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death. Rarely, patients present a variant of familial hypertrophic cardiomyopathy, characterized by mid-left ventricular chamber thickening. Note=The disease is caused by mutations affecting the gene represented in this entry. Similarity: Contains 3 EF-hand domains. Database links: Entrez Gene: 4634 Human Entrez Gene: 17897 Mouse Entrez Gene: 24585 Rat Omim: 160790 Human SwissProt: P08590 Human SwissProt: P09542 Mouse SwissProt: P16409 Rat Unigene: 517939 Human Unigene: 7353 Mouse Unigene: 1955 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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