Product Name	Anti-TMEFF2/RBITC
Chinese Name	罗丹明（RBITC）标记的增生性息肉蛋白1抗体
Alias	Tomoregulin-2; HPP 1; HPP1; Hyperplastic polyposis protein 1; TEFF 2; TEFF2; TENB 2; TENB2; Tomoregulin; TPEF; TR; Transmembrane protein containing epidermal growth factor and follistatin domains ; Transmembrane protein TENB2; Transmembrane protein with EGF like and two follistatin like domains 2; TEFF2_HUMAN.
Research Area	Tumour  Cell biology  immunology  Neurobiology  Growth factors and hormones
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human, Rat,  (predicted: Mouse, Chicken, Dog, Pig, Cow, Horse, Rabbit, Guinea Pig, )
Applications	IF=1:50-200  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Molecular weight	37kDa
Form	Lyophilized or Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human TMEFF2 C-terminus
Lsotype	IgG
Purification	affinity purified by Protein A
Storage Buffer	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Product Detail	background: TMEFF2 is a growth factor implicated in the progression of prostate cancer. It is highly expressed in the brain and may act as a survival factor for mesencephalic and hippocampal neurons. Function: May be a survival factor for hippocampal and mesencephalic neurons. The shedded form up-regulates cancer cell proliferation, probably by promoting ERK1/2 phosphorylation. Subcellular Location: Isoform 1: Membrane; Single-pass type I membrane protein (Potential). Isoform 2: Membrane; Single-pass type I membrane protein (Potential). Isoform 3: Secreted. Tissue Specificity: Highly expressed in adult and fetal brain, spinal cord and prostate. Expressed in all brain regions except the pituitary gland, with highest levels in amygdala and corpus callosum. Expressed in the pericryptal myofibroblasts and other stromal cells of normal colonic mucosa. Expressed in prostate carcinoma. Down-regulated in colorectal cancer. Present in Alzheimer disease plaques (at protein level). Isoform 3 is expressed weakly in testis and at high levels in normal and cancerous prostate. Post-translational modifications: N-glycosylated. Contains chondroitin sulfate glycosaminoglycans. A soluble form (TMEFF2-ECD) is produced by proteolytic shedding. This shedding can be induced by phorbol ester or proinflammatory cytokines such as TNFalpha, and is mediated by ADAM17. Similarity: Belongs to the tomoregulin family. Contains 1 EGF-like domain. Contains 2 Kazal-like domains. Database links: Entrez Gene: 538354 Cow Entrez Gene: 23671 Human Entrez Gene: 56363 Mouse Omim: 605734 Human SwissProt: Q17QD6 Cow SwissProt: Q9UIK5 Human SwissProt: Q9QYM9 Mouse Unigene: 144513 Human Unigene: 245154 Mouse Unigene: 445120 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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