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Product Name Anti-CXCL13/BCA1/RBITC Chinese Name 罗丹明(RBITC)标记的B-lymphocyteChemokine抗体 Alias C-X-C motif chemokine 13; Angie; ANGIE; ANGIE2; B cell-attracting chemokine 1; B cell attracting chemokine 1; B lymphocyte chemoattractant; B-cell chemoattractant; B-cell-attracting chemokine 1; B-cell-homing chemokine (ligand for Burkitt's lymphoma receptor-1); CXL13_MOUSE; BCA-1; BLC; BLR1L; Chemokine (C-X-C motif) ligand 13; Chemokine (C-X-C motif) ligand 13 (B-cell chemoattractant); Chemokine, CXC motif, ligand 13; CXC chemokine BLC; CXCL13; SCYB13; Small inducible cytokine B subfamily (Cys-X-Cys motif), member 13 (B-cell chemoattractant); Small-inducible cytokine B13; Small inducible cytokine B13; Small inducible cytokine subfamily B, member 13. Research Area Cell biology immunology Chemokine b-lymphocyte Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Mouse, Rat, ) Applications IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Molecular weight 10kDa Form Lyophilized or Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from mouse CXCL13/BCA1 Lsotype IgG Purification affinity purified by Protein A Storage Buffer 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. Product Detail background:
B lymphocyte chemoattractant, independently cloned and named Angie, is a CXC chemokine strongly expressed in the follicles of the spleen, lymph nodes, and Peyer's patches. It preferentially promotes the migration of B lymphocytes (compared to T cells and macrophages), apparently by stimulating calcium influx into, and chemotaxis of, cells expressing Burkitt's lymphoma receptor 1 (BLR1). It may therefore function in the homing of B lymphocytes to follicles.
Function:
Strongly chemotactic for B-lymphocytes, weakly for spleen monocytes and macrophages but no chemotactic activity for granulocytes. Binds to BLR1/CXCR5. May play a role in directing the migration of B-lymphocytes to follicles in secondary lymphoid organs.
Subcellular Location:
Secreted.
Tissue Specificity:
Found in spleen (B-cell-rich zone or follicles), Peyer patches (strongest within germinal centers and extending to the mantle zone) and lymph nodes (in reticular pattern in follicles).
Similarity:
Belongs to the intercrine alpha (chemokine CxC) family.
Database links:Entrez Gene: 10563 Human
Entrez Gene: 55985 Mouse
Omim: 605149 Human
SwissProt: O43927 Human
SwissProt: O55038 Mouse
Unigene: 100431 Human
Unigene: 10116 Mouse
Unigene: 6917 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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