Product Name	Anti-SERINC3/RBITC
Chinese Name	罗丹明（RBITC）标记的丝氨酸合并蛋白3抗体（Tumour差异表达蛋白）
Alias	TMS 1; TMS-1; AIGP1; DIFF33; SBBI99; serine incorporator 3; TDE; TDE1; Tumor differentially expressed protein 1; SERC3_HUMAN.
Research Area	Tumour  immunology  TumourCell biologyMaker
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Mouse,  (predicted: Human, Rat, Chicken, Dog, Cow, Horse, Rabbit, )
Applications	ICC=1:50-200 IF=1:50-200  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Molecular weight	53kDa
Form	Lyophilized or Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human SERINC3
Lsotype	IgG
Purification	affinity purified by Protein A
Storage Buffer	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Product Detail	background: TDE1, tumor differentially expressed protein 1, is a multi-pass membrane protein also known as serine incorporator 3. Also found on the membranes of the Golgi apparatus within cells, TDE1 is highly expressed in neuronal populations but is also found in thymus, kidney, liver and testis. Expression levels of TDE1 in tumors can be as much as tenfold the amount found in normal tissue of the same type. This increased expression implicates TDE1 as being involved in the cellular transformation from normal to malignant tissue. It is believed TDE1 contributes to oncogenesis by partially protecting cells from serum starvation and etoposide-induced apoptosis. The mechanism through which TDE1 protects cells is poorly understood, but may involve aberrant methylation of TDE1 complexes. Function: May be involved in cellular transformation. Subcellular Location: Cell membrane; Multi-pass membrane protein. Tissue Specificity: Ubiquitous. Expression levels were increased fourfold to tenfold in lung tumor tissues compared with normal pulmonary tissues. Post-translational modifications: N-glycosylated. Similarity: Belongs to the TDE1 family. Database links: Entrez Gene: 10955 Human Entrez Gene: 26943 Mouse Entrez Gene: 296350 Rat Omim: 607165 Human SwissProt: Q13530 Human SwissProt: Q9QZI9 Mouse Unigene: 272168 Human Unigene: 218473 Mouse Unigene: 3775 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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