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Product Name Anti-MAGEF1/RBITC Chinese Name 罗丹明(RBITC)标记的黑色素瘤抗原F蛋白家族1抗体 Alias MAGE F1 antigen; MAGEF 1; Melanoma antigen family F, 1; Melanoma associated antigen F1; MGC19617; MAGF1_HUMAN. Research Area Tumour Cell biology immunology Chromatin and nuclear signals Signal transduction Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Dog, Pig, ) Applications IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Molecular weight 35kDa Form Lyophilized or Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human MAGEF1 Lsotype IgG Purification affinity purified by Protein A Storage Buffer 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. Product Detail background:
MAGEF1 is a member of the MAGE (melanoma antigen gene) superfamily. Most known members of the MAGE superfamily are expressed in tumors, testis and fetal tissues, which has been described as a cancer/testis or "CT" expression pattern. MAGEF1, however, is expressed in all adult and fetal tissues tested, as well as in many tumor types including ovarian, breast, cervical, melanoma and leukemia. The coding region of MAGE-F1 is contained within a single exon and includes a microsatellite repeat. Several MAGE genes are ubiquitously expressed suggesting a role for MAGE encoded proteins in normal cell physiology.
Function:
May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex.
Subunit:
Interacts with LNX1, TRIM27 and NSMCE1.
Tissue Specificity:
Ubiquitous.
Similarity:
Contains 1 MAGE domain.
Database links:
UniProtKB/Swiss-Prot: Q9HAY2.2
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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