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Rabbit Anti-HMPH/RBITC Conjugated antibody
Rabbit Anti-HMPH/RBITC Conjugated antibody
Hematopoietically expressed homeobox; Hematopoietically-expressed homeobox protein HHEX; HEX; HHEX; HHEX_HUMAN; HMPH; Homeobox protein HEX; Homeobox protein PRH; HOX11L PEN; PRH; PRHX.
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Details

Product Name Anti-HMPH/RBITC
Chinese Name 罗丹明(RBITC)标记的同源盒蛋白PRH抗体
Alias Hematopoietically expressed homeobox; Hematopoietically-expressed homeobox protein HHEX; HEX; HHEX; HHEX_HUMAN; HMPH; Homeobox protein HEX; Homeobox protein PRH; HOX11L PEN; PRH; PRHX.  
Research Area Developmental biology  Signal transduction  Stem cells  
Immunogen Species Rabbit
Clonality Polyclonal
React Species (predicted: Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, )
Applications IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
Molecular weight 30kDa
Form Lyophilized or Liquid
Concentration 1mg/ml
immunogen KLH conjugated synthetic peptide derived from human HHEX/HMPH
Lsotype IgG
Purification affinity purified by Protein A
Storage Buffer 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Product Detail background:
Recognizes the DNA sequence 5'-ATTAA-3'. Transcriptional repressor. May play a role in hematopoietic differentiation. Establishes anterior identity at two levels; acts early to enhance canonical WNT-signaling by repressing expression of TLE4, and acts later to inhibit NODAL-signaling by directly targeting NODAL.

Function:
Recognizes the DNA sequence 5'-ATTAA-3'. Transcriptional repressor. May play a role in hematopoietic differentiation. Establishes anterior identity at two levels; acts early to enhance canonical WNT-signaling by repressing expression of TLE4, and acts later to inhibit NODAL-signaling by directly targeting NODAL (By similarity).

Subcellular Location:
Nucleus (Probable).

Tissue Specificity:
Liver and promyelocytic leukemia cell line HL60.

Similarity:
Contains 1 homeobox DNA-binding domain.

Database links:

Entrez Gene: 3087 Human

Entrez Gene: 15242 Mouse

Entrez Gene: 397232 Pig

Entrez Gene: 79237 Rat

Omim: 604420 Human

SwissProt: Q03014 Human

SwissProt: P43120 Mouse

Unigene: 118651 Human

Unigene: 33896 Mouse

Unigene: 12188 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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