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Rabbit Anti-Transglutaminase-1/RBITC Conjugated antibody
Rabbit Anti-Transglutaminase-1/RBITC Conjugated antibody
TGM1_HUMAN; Epidermal TGase; ICR 2; ICR2; K polypeptide epidermal type I; KTG; LI 1; LI; LI1; Protein glutamine gamma glutamyltransferase K; TG(K); TGase 1; TGASE; TGase K; TGase1; TGaseK; TGK; Tgm 1; Tgm1 antibody Transglutaminase 1; Transglutaminase 1;
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Product Name Anti-Transglutaminase-1/RBITC
Chinese Name 罗丹明(RBITC)标记的谷氨酰胺转胺酶1抗体
Alias TGM1_HUMAN; Epidermal TGase; ICR 2; ICR2; K polypeptide epidermal type I; KTG; LI 1; LI; LI1; Protein glutamine gamma glutamyltransferase K; TG(K); TGase 1; TGASE; TGase K; TGase1; TGaseK; TGK; Tgm 1; Tgm1 antibody Transglutaminase 1; Transglutaminase 1; Transglutaminase K; Transglutaminase keratinocyte; Transglutaminase1; TransglutaminaseK.  
Research Area Signal transduction  Binding protein  
Immunogen Species Rabbit
Clonality Polyclonal
React Species Rat,  (predicted: Human, Mouse, Dog, Pig, )
Applications IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
Molecular weight 90kDa
Form Lyophilized or Liquid
Concentration 1mg/ml
immunogen KLH conjugated synthetic peptide derived from human Transglutaminase-1
Lsotype IgG
Purification affinity purified by Protein A
Storage Buffer 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Product Detail background:
Tissue transglutaminase is a calcium activated enzyme which catalyzes the cross linking of proteins and the conjugation of polyamines to proteins. The identification of transglutaminase as the main antigen of endomysium antibodies allows a new diagnostic approach to celiac disease (CD). CD, a genetic, immunologically mediated small bowel enteropathy that causes malabsorption, is a relatively common disorder in Western countries.

Function:
Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins. Responsible for cross-linking epidermal proteins during formation of the stratum corneum.

Subcellular Location:
Membrane; Lipid-anchor.

Similarity:
Belongs to the transglutaminase superfamily.

Database links:

Entrez Gene: 7051 Human

Omim: 190195 Human

SwissProt: P22735 Human

Unigene: 508950 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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