Product Name	Anti-FRS2/RBITC
Chinese Name	罗丹明（RBITC）标记的成纤维细胞生长因子受体底物2抗体
Alias	FGFR signaling adaptor SNT; FGFR signalling adaptor; FGFR substrate 2; FGFR-signaling adaptor SNT; Fibroblast Growth Factor Receptor Substrate 2; FRS 2; FRS2_HUMAN; FRS2A; FRS2alpha; SNT 1; SNT; SNT-1; SNT1; Suc 1 Associated Neurotrophic Factor Target; Suc1 associated neurotrophic factor target 1; Suc1-associated neurotrophic factor target 1.
Research Area	Cell biology  Neurobiology  Signal transduction  Growth factors and hormones  The cell membrane受体
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Rat,  (predicted: Human, Mouse, Pig, Cow, Horse, Rabbit, )
Applications	IF=1:50-200  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Molecular weight	57kDa
Form	Lyophilized or Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human FRS2
Lsotype	IgG
Purification	affinity purified by Protein A
Storage Buffer	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Product Detail	Function: Adapter protein that links FGR and NGF receptors to downstream signaling pathways. Involved in the activation of MAP kinases. Modulates signaling via SHC1 by competing for a common binding site on NTRK1. Subunit: Contains 1 IRS-type PTB domain. Subcellular Location: Endomembrane system. Cytoplasmic, membrane-bound. Tissue Specificity: Highly expressed in heart, brain, spleen, lung, liver, skeletal muscle, kidney and testis. Post-translational modifications: Phosphorylated by ULK2 in vitro. Phosphorylated on tyrosine residues upon stimulation by NGF or FGF2. Phosphorylated on tyrosine residues by activated ALK and FGFR1. Phosphorylated on tyrosine residues upon activation of FGFR2 and FGFR3. Phosphorylated on threonine residues by MAP kinases; this inhibits tyrosine phosphorylation, and thereby down-regulates FRS2-mediated activation of MAP kinases. Ubiquitinated when tyrosine phosphorylated and in a complex with GRB2. The unphosphorylated form is not subject to ubiquitination. Similarity: Contains 1 IRS-type PTB domain. Database links: Entrez Gene: 10818 Human Entrez Gene: 327826 Mouse Entrez Gene: 314850 Rat Omim: 607743 Human SwissProt: Q8WU20 Human SwissProt: Q8C180 Mouse Unigene: 593446 Human Unigene: 135965 Mouse Unigene: 22182 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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