Product Name	Anti-APCDD1/PE
Chinese Name	PE标记的腺瘤性息肉调节蛋白抗体
Alias	adenomatosio polyposis coli down-regulated 1; Adenomatosis polyposis coli down regulated 1; Adenomatosis polyposis coli down regulated 1 protein; APCDD 1; B7323; DRAPC1; FP7019; Protein APCDD1; APCD1_HUMAN.
Research Area	Tumour  immunology  Growth factors and hormones
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Chicken, Dog, Rabbit, )
Applications	IF=1:50-200  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Molecular weight	56kDa
Form	Lyophilized or Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human APCDD1
Lsotype	IgG
Purification	affinity purified by Protein A
Storage Buffer	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Product Detail	background: APCDD1 is a novel protein that has been shown to be a target of Wnt/beta catenin signaling pathway in cancer cell lines. APCDD1 is overexpressed in colorectal carcinogenesis and is deregulated in CTNNB1 mutated Wilms tumors. [FUNCTION] Probably plays a role in colorectal tumorigenesis. May be a developmental target gene of the Wnt/Beta-catenin pathway. [SUBCELLULAR LOCATION] Membrane; Single-pass type I membrane protein (Potential). [TISSUE SPECIFICITY] Abundantly expressed in heart, pancreas, prostate and ovary. Moderately expressed in lung, liver, kidney, spleen, thymus, colon and peripheral lymphocytes. [INDUCTION] Transcriptionally regulated by the CTNNB1/TF7L2complex. Function: Negative regulator of the Wnt signaling pathway. Inhibits Wnt signaling in a cell-autonomous manner and functions upstream of beta-catenin. May act via its interaction with Wnt and LRP proteins. May play a role in colorectal tumorigenesis. Subunit: Homodimer. Interacts with LRP5 and WNT3A. Subcellular Location: Cell membrane; Single-pass type I membrane protein. Tissue Specificity: Abundantly expressed in heart, pancreas, prostate and ovary. Moderately expressed in lung, liver, kidney, spleen, thymus, colon and peripheral lymphocytes. Abundantly expressed in both the epidermal and dermal compartments of the hair follicle. Present in scalp skin Highly expressed in the hair follicle dermal papilla, the matrix, and the hair shaft (at protein level). Post-translational modifications: N-Glycosylated. DISEASE: Hypotrichosis 1 (HYPT1) [MIM:605389]: A rare form of non-syndromic hereditary hypotrichosis without characteristic hair shaft anomalies. Affected individuals typically show normal hair at birth, but hair loss and thinning of the hair shaft start during early childhood and progress with age. Note=The disease is caused by mutations affecting the gene represented in this entry. Similarity: Belongs to the APCDD1 family. Database links: Entrez Gene: 147495 Human Entrez Gene: 494504 Mouse Omim: 607479 Human SwissProt: Q8J025 Human SwissProt: Q3U128 Mouse Unigene: 293274 Human Unigene: 391102 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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